Neil Kaplowitz
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Explore the profile of Neil Kaplowitz including associated specialties, affiliations and a list of published articles.
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150
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7707
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Recent Articles
1.
Chandrashekar D, Roules G, Jagadeesan N, Panchal U, Oyegbesan A, Imiruaye O, et al.
Neurobiol Dis
. 2024 Jun;
199:106570.
PMID: 38885850
Background: Hepatic lipoprotein receptor-related protein 1 (LRP-1) plays a central role in peripheral amyloid beta (Aβ) clearance, but its importance in Alzheimer's disease (AD) pathology is understudied. Our previous work...
2.
Win S, Than T, Kaplowitz N
Front Cell Dev Biol
. 2024 Apr;
12:1359152.
PMID: 38559813
Cell death occurs in various circumstances, such as homeostasis, stress response, and defense, specific pathways and mechanisms that are regulated by specific activator-induced signal transductions. Among them, Jun N-terminal kinases...
3.
Li D, Chen Y, Wan M, Mei F, Wang F, Gu P, et al.
Cell Host Microbe
. 2023 Dec;
32(1):48-62.e9.
PMID: 38056458
Acetaminophen overuse is a common cause of acute liver failure (ALF). During ALF, toxins are metabolized by enzymes such as CYP2E1 and transformed into reactive species, leading to oxidative damage...
4.
Garcia-Cortes M, Ortega-Alonso A, Matilla-Cabello G, Medina-Caliz I, Castiella A, Conde I, et al.
Liver Int
. 2023 Jun;
43(8):1749-1760.
PMID: 37269163
Background & Aims: Idiosyncratic drug-induced liver injury (DILI) with autoimmune features is a liver condition with laboratory and histological characteristics similar to those of idiopathic autoimmune hepatitis (AIH), which despite...
5.
Win S, Than T, Kaplowitz N
Antioxid Redox Signal
. 2022 Nov;
38(16-18):1071-1081.
PMID: 36333933
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States. Liver glutathione (GSH) depletion and sustained P-JNK (c--N-terminal kinase) activation are key modulators in...
6.
Garcia J, Chang R, Steinberg R, Arce A, Yang J, Van Der Eb P, et al.
Front Physiol
. 2022 Oct;
13:930402.
PMID: 36187787
Heavy alcohol consumption is a known risk factor for various forms of dementia and the development of Alzheimer's disease (AD). In this work, we investigated how intragastric alcohol feeding may...
7.
Ajoolabady A, Kaplowitz N, Lebeaupin C, Kroemer G, Kaufman R, Malhi H, et al.
Hepatology
. 2022 May;
77(2):619-639.
PMID: 35524448
The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding of linear polypeptides and proteins, a process tightly governed by the ER-resident enzymes and chaperones. Failure to...
8.
Li R, Xie L, Li L, Chen X, Yao T, Tian Y, et al.
Acta Pharm Sin B
. 2022 Feb;
12(1):182-196.
PMID: 35127379
Hepatic ischemia/reperfusion injury (HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development of liver injury. Herein,...
9.
10.
Win S, Min R, Zhang J, Kanel G, Wanken B, Chen Y, et al.
Hepatology
. 2021 Jul;
74(6):3127-3145.
PMID: 34331779
Background And Aims: The hepatic mitogen-activated protein kinase (MAPK) cascade leading to c-Jun N-terminal kinase (JNK) activation has been implicated in the pathogenesis of nonalcoholic fatty liver (NAFL)/NASH. In acute...