Prevalence of and Risk Factors for Anal Human Papillomavirus Infection in Men Who Have Sex with Women: a Cross-national Study

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2010 Apr 7

PMID 20367457

Citations 38

Authors

Alan G Nyitray

Danelle Smith

Luisa Villa

Eduardo Lazcano-Ponce

Martha Abrahamsen

Mary Papenfuss

Anna R Giuliano

Affiliations

Soon will be listed here.

Abstract

Background: Although the primary cause of anal cancer is human papillomavirus (HPV) infection in the anal canal, little attention has been paid to the epidemiology of anal HPV infection in men who have sex with women (MSW).

Methods: Exfoliated cells from the anal canal of 902 MSW in Brazil (São Paulo), Mexico (Cuernavaca), and the United States (Tampa) were tested for HPV DNA.

Results: The prevalence of HPV infection in the anal canal (12.0%) was similar among MSW in each city (P=.77), whereas 7.0% had infection with oncogenic types. Men in Tampa had a 4-fold higher prevalence of infection with HPV type 16 (HPV-16) than that among men in São Paulo or Cuernavaca (P<.001). Duration of relationship with a primary sex partner and ever having oral or anal sex with a man was associated with infection with any HPV type and with any oncogenic type, whereas lifetime number of female sex partners was associated with infection with any HPV type.

Conclusions: Anal canal HPV infection is commonly found among MSW, and the prevalence of infection with HPV-16 may differ substantially by geography. Men who have a larger lifetime number of female sex partners, who are in a sexual relationship of <1 year in duration, and who have a history of oral or anal sex with men were most likely to have an anal HPV infection.

Citing Articles

The Epidemiology of Anal Human Papillomavirus (HPV) in HIV-Positive and HIV-Negative Women and Men: A Ten-Year Retrospective Observational Study in Rome (Italy).

Fracella M, Oliveto G, Roberto P, Cinti L, Gentile M, Coratti E Pathogens. 2024; 13(2).

PMID: 38392901 PMC: 10892302. DOI: 10.3390/pathogens13020163.

The Immune Response Generated against HPV Infection in Men and Its Implications in the Diagnosis of Cancer.

Chihu-Amparan L, Pedroza-Saavedra A, Gutierrez-Xicotencatl L Microorganisms. 2023; 11(6).

PMID: 37375112 PMC: 10301280. DOI: 10.3390/microorganisms11061609.

Type-specific concurrent anogenital HPV detection among young women and MSM attending Dutch sexual health clinics.

Kusters J, Heijne J, van Benthem B, King A, Schim van der Loeff M Sex Transm Infect. 2022; .

PMID: 35842228 PMC: 10313988. DOI: 10.1136/sextrans-2022-055484.

The Association between Smoking and Anal Human Papillomavirus in the HPV Infection in Men Study.

Umutoni V, Schabath M, Nyitray A, Wilkin T, Villa L, Lazcano-Ponce E Cancer Epidemiol Biomarkers Prev. 2022; 31(8):1546-1553.

PMID: 35653709 PMC: 9350906. DOI: 10.1158/1055-9965.EPI-21-1373.

Human Papillomavirus associated prevention: knowledge, attitudes, and perceived risks among men who have sex with men and transgender women in Pakistan: a qualitative study.

Ejaz M, Ekstrom A, Ahmed A, Haroon A, Ali D, Ali T BMC Public Health. 2022; 22(1):378.

PMID: 35193544 PMC: 8864907. DOI: 10.1186/s12889-022-12775-z.

References

Caceres C, Konda K, Pecheny M, Chatterjee A, Lyerla R . Estimating the number of men who have sex with men in low and middle income countries. Sex Transm Infect. 2006; 82 Suppl 3:iii3-9. PMC: 2576725. DOI: 10.1136/sti.2005.019489. View

Daling J, Madeleine M, Johnson L, Schwartz S, Shera K, Wurscher M . Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer. Cancer. 2004; 101(2):270-80. DOI: 10.1002/cncr.20365. View

Nyitray A, Kim J, Hsu C, Papenfuss M, Villa L, Lazcano-Ponce E . Test-retest reliability of a sexual behavior interview for men residing in Brazil, Mexico, and the United States: the HPV in Men (HIM) Study. Am J Epidemiol. 2009; 170(8):965-74. PMC: 2765366. DOI: 10.1093/aje/kwp225. View

Sonnex C, Strauss S, Gray J . Detection of human papillomavirus DNA on the fingers of patients with genital warts. Sex Transm Infect. 2000; 75(5):317-9. PMC: 1758241. DOI: 10.1136/sti.75.5.317. View

Giuliano A, Lazcano E, Villa L, Flores R, Salmeron J, Lee J . Circumcision and sexual behavior: factors independently associated with human papillomavirus detection among men in the HIM study. Int J Cancer. 2008; 124(6):1251-7. PMC: 3466048. DOI: 10.1002/ijc.24097. View

Gravitt P, Peyton C, Apple R, Wheeler C . Genotyping of 27 human papillomavirus types by using L1 consensus PCR products by a single-hybridization, reverse line blot detection method. J Clin Microbiol. 1998; 36(10):3020-7. PMC: 105104. DOI: 10.1128/JCM.36.10.3020-3027.1998. View

Hewett P, Mensch B, Ribeiro M, Jones H, Lippman S, Montgomery M . Using sexually transmitted infection biomarkers to validate reporting of sexual behavior within a randomized, experimental evaluation of interviewing methods. Am J Epidemiol. 2008; 168(2):202-11. PMC: 3290925. DOI: 10.1093/aje/kwn113. View

Gross M, Holte S, Marmor M, Mwatha A, Koblin B, Mayer K . Anal sex among HIV-seronegative women at high risk of HIV exposure. The HIVNET Vaccine Preparedness Study 2 Protocol Team. J Acquir Immune Defic Syndr. 2000; 24(4):393-8. DOI: 10.1097/00126334-200008010-00015. View

Nicolau S, Camargo C, Stavale J, Castelo A, Dores G, Lorincz A . Human papillomavirus DNA detection in male sexual partners of women with genital human papillomavirus infection. Urology. 2005; 65(2):251-5. DOI: 10.1016/j.urology.2004.09.031. View

10.

Nielson C, Harris R, Dunne E, Abrahamsen M, Papenfuss M, Flores R . Risk factors for anogenital human papillomavirus infection in men. J Infect Dis. 2007; 196(8):1137-45. PMC: 3877918. DOI: 10.1086/521632. View

11.

Carter J, Madeleine M, Shera K, Schwartz S, Cushing-Haugen K, Wipf G . Human papillomavirus 16 and 18 L1 serology compared across anogenital cancer sites. Cancer Res. 2001; 61(5):1934-40. View

12.

Wong A, Chan R, Aggarwal N, Singh M, Nichols W, Bose S . Human papillomavirus genotypes in anal intraepithelial neoplasia and anal carcinoma as detected in tissue biopsies. Mod Pathol. 2009; 23(1):144-50. DOI: 10.1038/modpathol.2009.143. View

13.

Sanchez A, Schreiber G, Glynn S, Bethel J, Kessler D, Chang D . Blood-donor perceptions of health history screening with a computer-assisted self-administered interview. Transfusion. 2003; 43(2):165-72. DOI: 10.1046/j.1537-2995.2003.00295.x. View

14.

Joseph D, Miller J, Wu X, Chen V, Morris C, Goodman M . Understanding the burden of human papillomavirus-associated anal cancers in the US. Cancer. 2008; 113(10 Suppl):2892-900. PMC: 2729501. DOI: 10.1002/cncr.23744. View

15.

de Sanjose S, Diaz M, Castellsague X, Clifford G, Bruni L, Munoz N . Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis. 2007; 7(7):453-9. DOI: 10.1016/S1473-3099(07)70158-5. View

16.

Wilkin T, Palmer S, Brudney K, Chiasson M, Wright T . Anal intraepithelial neoplasia in heterosexual and homosexual HIV-positive men with access to antiretroviral therapy. J Infect Dis. 2004; 190(9):1685-91. DOI: 10.1086/424599. View

17.

Maggard M, Beanes S, Ko C . Anal canal cancer: a population-based reappraisal. Dis Colon Rectum. 2003; 46(11):1517-23. DOI: 10.1097/01.DCR.0000093722.63657.B4. View

18.

Giuliano A, Lazcano-Ponce E, Villa L, Flores R, Salmeron J, Lee J . The human papillomavirus infection in men study: human papillomavirus prevalence and type distribution among men residing in Brazil, Mexico, and the United States. Cancer Epidemiol Biomarkers Prev. 2008; 17(8):2036-43. PMC: 3471778. DOI: 10.1158/1055-9965.EPI-08-0151. View

19.

Chin-Hong P, Vittinghoff E, Cranston R, Buchbinder S, Cohen D, Colfax G . Age-Specific prevalence of anal human papillomavirus infection in HIV-negative sexually active men who have sex with men: the EXPLORE study. J Infect Dis. 2004; 190(12):2070-6. DOI: 10.1086/425906. View

20.

Moscicki A, Durako S, Houser J, Ma Y, Murphy D, Darragh T . Human papillomavirus infection and abnormal cytology of the anus in HIV-infected and uninfected adolescents. AIDS. 2003; 17(3):311-20. DOI: 10.1097/00002030-200302140-00004. View