Detection of Human Papillomavirus DNA on the Fingers of Patients with Genital Warts

Overview

Journal Sex Transm Infect

Specialty Infectious Diseases

Date 2000 Jan 5

PMID 10616355

Citations 46

Authors

C Sonnex

S Strauss

J J Gray

Affiliations

Soon will be listed here.

Abstract

Objective: To determine whether patients with genital warts carry human papillomavirus (HPV) DNA on their fingers.

Methods: 14 men and eight women with genital warts had cytobrush samples taken from genital lesions, finger tips, and tips of finger nails. Samples were examined for the presence of HPV DNA by the polymerase chain reaction.

Results: HPV DNA was detected in all female genital samples and in 13/14 male genital samples. HPV DNA was detected in the finger brush samples of three women and nine men. The same HPV type was identified in genital and hand samples in one woman and five men.

Conclusion: This study has identified hand carriage of genital HPV types in patients with genital warts. Although sexual intercourse is considered the usual mode of transmitting genital HPV infection, our findings raise the possibility of transmission by finger-genital contact.

Citing Articles

Update on Squamous Cell Carcinoma of the Nail Unit: An Human Papillomavirus-Associated Condition.

Bray E, Tosti A, Morrison B Skin Appendage Disord. 2024; 10(3):199-206.

PMID: 38835716 PMC: 11147528. DOI: 10.1159/000537760.

The role of HPV in the etiopathogenesis of pterygium and the relationship with recurrence.

Nergiz D, Suren E, Suren D Int Ophthalmol. 2023; 43(10):3793-3801.

PMID: 37422852 DOI: 10.1007/s10792-023-02791-2.

Human Papillomavirus Infection during Pregnancy and Childhood: A Comprehensive Review.

Ardekani A, Taherifard E, Mollalo A, Hemadi E, Roshanshad A, Fereidooni R Microorganisms. 2022; 10(10).

PMID: 36296208 PMC: 9607260. DOI: 10.3390/microorganisms10101932.

Seroprevalence of mucosal and cutaneous human papillomavirus (HPV) types among children and adolescents in the general population in Germany.

Loenenbach A, Pawlita M, Waterboer T, Harder T, Poethko-Muller C, Thamm M BMC Infect Dis. 2022; 22(1):44.

PMID: 35012452 PMC: 8751243. DOI: 10.1186/s12879-022-07028-8.

Human Papillomavirus Related Neoplasia of the Ocular Adnexa.

Ramberg I, Heegaard S Viruses. 2021; 13(8).

PMID: 34452388 PMC: 8402806. DOI: 10.3390/v13081522.

References

Rock B, Naghashfar Z, Barnett N, Buscema J, Woodruff J, Shah K . Genital tract papillomavirus infection in children. Arch Dermatol. 1986; 122(10):1129-32. View

Meyer T, Arndt R, Christophers E, Beckmann E, Schroder S, Gissmann L . Association of rare human papillomavirus types with genital premalignant and malignant lesions. J Infect Dis. 1998; 178(1):252-5. DOI: 10.1086/517447. View

Schneider A, Braun R, Kimmig R, Koldovsky U, SCHNEWEIS K, Seedorf K . Antibodies against the human papillomavirus type 16 early proteins in human sera: correlation of anti-E7 reactivity with cervical cancer. J Natl Cancer Inst. 1989; 81(22):1698-704. DOI: 10.1093/jnci/81.22.1698. View

Gibson P, Gardner S, Best S . Human papillomavirus types in anogenital warts of children. J Med Virol. 1990; 30(2):142-5. DOI: 10.1002/jmv.1890300212. View

Tay S, Ho T, Lim-Tan S . Is genital human papillomavirus infection always sexually transmitted?. Aust N Z J Obstet Gynaecol. 1990; 30(3):240-2. DOI: 10.1111/j.1479-828x.1990.tb03223.x. View

Bauer H, Ting Y, Greer C, Chambers J, Tashiro C, Chimera J . Genital human papillomavirus infection in female university students as determined by a PCR-based method. JAMA. 1991; 265(4):472-7. View

Ley C, Bauer H, Reingold A, Schiffman M, Chambers J, Tashiro C . Determinants of genital human papillomavirus infection in young women. J Natl Cancer Inst. 1991; 83(14):997-1003. DOI: 10.1093/jnci/83.14.997. View

Tawheed A, Beaudenon S, Favre M, Orth G . Characterization of human papillomavirus type 66 from an invasive carcinoma of the uterine cervix. J Clin Microbiol. 1991; 29(11):2656-60. PMC: 270399. DOI: 10.1128/jcm.29.11.2656-2660.1991. View

Lungu O, Wright Jr T, Silverstein S . Typing of human papillomaviruses by polymerase chain reaction amplification with L1 consensus primers and RFLP analysis. Mol Cell Probes. 1992; 6(2):145-52. DOI: 10.1016/0890-8508(92)90059-7. View

10.

Fairley C, Chen S, Tabrizi S, Leeton K, Quinn M, Garland S . The absence of genital human papillomavirus DNA in virginal women. Int J STD AIDS. 1992; 3(6):414-7. DOI: 10.1177/095646249200300602. View

11.

PAO C, Tsai P, Chang Y, Hsieh T, Jin J . Possible non-sexual transmission of genital human papillomavirus infections in young women. Eur J Clin Microbiol Infect Dis. 1993; 12(3):221-2. DOI: 10.1007/BF01967118. View

12.

Handley J, Dinsmore W, Maw R, Corbett R, Burrows D, Bharucha H . Anogenital warts in prepubertal children; sexual abuse or not?. Int J STD AIDS. 1993; 4(5):271-9. DOI: 10.1177/095646249300400505. View

13.

Shamanin V, Glover M, Rausch C, Proby C, Leigh I, zur Hausen H . Specific types of human papillomavirus found in benign proliferations and carcinomas of the skin in immunosuppressed patients. Cancer Res. 1994; 54(17):4610-3. View

14.

Shamanin V, zur Hausen H, Lavergne D, Proby C, Leigh I, Neumann C . Human papillomavirus infections in nonmelanoma skin cancers from renal transplant recipients and nonimmunosuppressed patients. J Natl Cancer Inst. 1996; 88(12):802-11. DOI: 10.1093/jnci/88.12.802. View

15.

Burk R, Ho G, Beardsley L, Lempa M, Peters M, Bierman R . Sexual behavior and partner characteristics are the predominant risk factors for genital human papillomavirus infection in young women. J Infect Dis. 1996; 174(4):679-89. DOI: 10.1093/infdis/174.4.679. View

16.

de Roda Husman A, Walboomers J, van den Brule A, Meijer C, Snijders P . The use of general primers GP5 and GP6 elongated at their 3' ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol. 1995; 76 ( Pt 4):1057-62. DOI: 10.1099/0022-1317-76-4-1057. View

17.

Fleming K, Venning V, Evans M . DNA typing of genital warts and diagnosis of sexual abuse of children. Lancet. 1987; 2(8556):454. DOI: 10.1016/s0140-6736(87)90987-1. View