The Immune Response Generated Against HPV Infection in Men and Its Implications in the Diagnosis of Cancer

Overview

Journal Microorganisms

Specialty Microbiology

Date 2023 Jun 28

PMID 37375112

Authors

Lilia Chihu-Amparan

Adolfo Pedroza-Saavedra

Lourdes Gutierrez-Xicotencatl

Affiliations

Soon will be listed here.

Abstract

Human papillomavirus (HPV) infection is associated with precancerous lesions and cancer of the genital tract both in women and men. The high incidence of cervical cancer worldwide focused the research on this infection mainly in women and to a lesser extent in men. In this review, we summarized epidemiological, immunological, and diagnostic data associated with HPV and cancer in men. We presented an overview of the main characteristics of HPV and infection in men that are associated with different types of cancer but also associated with male infertility. Men are considered important vectors of HPV transmission to women; therefore, identifying the sexual and social behavioral risk factors associated with HPV infection in men is critical to understand the etiology of the disease. It is also essential to describe how the immune response develops in men during HPV infection or when vaccinated, since this knowledge could help to control the viral transmission to women, decreasing the incidence of cervical cancer, but also could reduce other HPV-associated cancers among men who have sex with men (MSM). Finally, we summarized the methods used over time to detect and genotype HPV genomes, as well as some diagnostic tests that use cellular and viral biomarkers that were identified in HPV-related cancers.

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References

de Lima Rocha M, Faria F, Goncalves L, Souza M, Fernandes P, Fernandes A . Prevalence of DNA-HPV in male sexual partners of HPV-infected women and concordance of viral types in infected couples. PLoS One. 2012; 7(7):e40988. PMC: 3398875. DOI: 10.1371/journal.pone.0040988. View

Hillman R, Giuliano A, Palefsky J, Goldstone S, Moreira Jr E, Vardas E . Immunogenicity of the quadrivalent human papillomavirus (type 6/11/16/18) vaccine in males 16 to 26 years old. Clin Vaccine Immunol. 2011; 19(2):261-7. PMC: 3272915. DOI: 10.1128/CVI.05208-11. View

Nyitray A, Carvalho da Silva R, Baggio M, Lu B, Smith D, Abrahamsen M . Age-specific prevalence of and risk factors for anal human papillomavirus (HPV) among men who have sex with women and men who have sex with men: the HPV in men (HIM) study. J Infect Dis. 2010; 203(1):49-57. PMC: 3086435. DOI: 10.1093/infdis/jiq021. View

Weis S, Vecino I, Pogoda J, Susa J, Nevoit J, Radaford D . Prevalence of anal intraepithelial neoplasia defined by anal cytology screening and high-resolution anoscopy in a primary care population of HIV-infected men and women. Dis Colon Rectum. 2011; 54(4):433-41. DOI: 10.1007/DCR.0b013e318207039a. View

Abalos A, Harris R, Nyitray A, Mitchell A, Thompson P, Giuliano A . Human papillomavirus type distribution among heterosexual couples. J Low Genit Tract Dis. 2011; 16(1):10-5. DOI: 10.1097/LGT.0b013e31822a8404. View

Alemany L, Cubilla A, Halec G, Kasamatsu E, Quiros B, Masferrer E . Role of Human Papillomavirus in Penile Carcinomas Worldwide. Eur Urol. 2016; 69(5):953-61. DOI: 10.1016/j.eururo.2015.12.007. View

Lu B, Viscidi R, Wu Y, Nyitray A, Villa L, Lazcano-Ponce E . Seroprevalence of human papillomavirus (HPV) type 6 and 16 vary by anatomic site of HPV infection in men. Cancer Epidemiol Biomarkers Prev. 2012; 21(9):1542-6. PMC: 3466057. DOI: 10.1158/1055-9965.EPI-12-0483. View

Oriel J . Natural history of genital warts. Br J Vener Dis. 1971; 47(1):1-13. PMC: 1048137. DOI: 10.1136/sti.47.1.1. View

de Gruijl T, Bontkes H, Walboomers J, Coursaget P, Stukart M, Dupuy C . Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome. J Gen Virol. 1999; 80 ( Pt 2):399-408. DOI: 10.1099/0022-1317-80-2-399. View

10.

Cheng S, Chu F, Lin Y, Hsueh Y . Influence of age and CD4+ T cell counts on the prevalence of genital human papillomavirus infection among HIV-seropositive men who have sex with men in Taiwan. J Med Virol. 2012; 84(12):1876-83. DOI: 10.1002/jmv.23413. View

11.

Stanley M . HPV vaccination in boys and men. Hum Vaccin Immunother. 2014; 10(7):2109-11. PMC: 4186028. DOI: 10.4161/hv.29137. View

12.

Ondondo R, Bukusi E, Nganga Z, Kiptoo M, Mpoke S . Cellular immune responses against natural human papillomavirus infections among men in Kisumu, Kenya. Clin Immunol. 2019; 212:108211. DOI: 10.1016/j.clim.2019.05.001. View

13.

Souho T, Benlemlih M, Bennani B . Human papillomavirus infection and fertility alteration: a systematic review. PLoS One. 2015; 10(5):e0126936. PMC: 4436317. DOI: 10.1371/journal.pone.0126936. View

14.

Machalek D, Poynten M, Jin F, Fairley C, Farnsworth A, Garland S . Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis. Lancet Oncol. 2012; 13(5):487-500. DOI: 10.1016/S1470-2045(12)70080-3. View

15.

Guo T, Gaykalova D, Considine M, Wheelan S, Pallavajjala A, Bishop J . Characterization of functionally active gene fusions in human papillomavirus related oropharyngeal squamous cell carcinoma. Int J Cancer. 2016; 139(2):373-82. PMC: 5579720. DOI: 10.1002/ijc.30081. View

16.

Nyitray A, Lin H, Fulp W, Chang M, Menezes L, Lu B . The role of monogamy and duration of heterosexual relationships in human papillomavirus transmission. J Infect Dis. 2013; 209(7):1007-15. PMC: 3952669. DOI: 10.1093/infdis/jit615. View

17.

Zhang J, Chen X, Ye Y, Shen W, Ye X, Lin Y . Increased CD4 T cell count is associated with lower anal human papillomavirus prevalence among HIV-positive male cohort in Taizhou, China: a cross-sectional study. BMC Infect Dis. 2022; 22(1):250. PMC: 8919533. DOI: 10.1186/s12879-022-07251-3. View

18.

Palefsky J . Human papillomavirus-related disease in men: not just a women's issue. J Adolesc Health. 2010; 46(4 Suppl):S12-9. PMC: 2871537. DOI: 10.1016/j.jadohealth.2010.01.010. View

19.

. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015; 517(7536):576-82. PMC: 4311405. DOI: 10.1038/nature14129. View

20.

Stevenson A, Wakeham K, Pan J, Kavanagh K, Millan D, Bell S . Droplet digital PCR quantification suggests that higher viral load correlates with improved survival in HPV-positive oropharyngeal tumours. J Clin Virol. 2020; 129:104505. DOI: 10.1016/j.jcv.2020.104505. View