1918 Influenza: the Mother of All Pandemics

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2006 Feb 24

PMID 16494711

Citations 827

Authors

Jeffery K Taubenberger

David M Morens

Affiliations

Soon will be listed here.

Abstract

The "Spanish" influenza pandemic of 1918-1919, which caused approximately 50 million deaths worldwide, remains an ominous warning to public health. Many questions about its origins, its unusual epidemiologic features, and the basis of its pathogenicity remain unanswered. The public health implications of the pandemic therefore remain in doubt even as we now grapple with the feared emergence of a pandemic caused by H5N1 or other virus. However, new information about the 1918 virus is emerging, for example, sequencing of the entire genome from archival autopsy tissues. But, the viral genome alone is unlikely to provide answers to some critical questions. Understanding the 1918 pandemic and its implications for future pandemics requires careful experimentation and in-depth historical analysis.

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References

Reid A, Fanning T, Janczewski T, Taubenberger J . Characterization of the 1918 "Spanish" influenza virus neuraminidase gene. Proc Natl Acad Sci U S A. 2000; 97(12):6785-90. PMC: 18739. DOI: 10.1073/pnas.100140097. View

Matrosovich M, Gambaryan A, Teneberg S, Piskarev V, Yamnikova S, Lvov D . Avian influenza A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides and by a higher conservation of the HA receptor-binding site. Virology. 1997; 233(1):224-34. DOI: 10.1006/viro.1997.8580. View

Patterson K, Pyle G . The geography and mortality of the 1918 influenza pandemic. Bull Hist Med. 1991; 65(1):4-21. View

Kash J, Basler C, Garcia-Sastre A, Carter V, Billharz R, Swayne D . Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus. J Virol. 2004; 78(17):9499-511. PMC: 506954. DOI: 10.1128/JVI.78.17.9499-9511.2004. View

Taubenberger J, Reid A, Lourens R, Wang R, Jin G, Fanning T . Characterization of the 1918 influenza virus polymerase genes. Nature. 2005; 437(7060):889-93. DOI: 10.1038/nature04230. View

Peiris J, Yu W, Leung C, Cheung C, Ng W, Nicholls J . Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet. 2004; 363(9409):617-9. PMC: 7112424. DOI: 10.1016/S0140-6736(04)15595-5. View

BEAN W, Schell M, Katz J, Kawaoka Y, Naeve C, Gorman O . Evolution of the H3 influenza virus hemagglutinin from human and nonhuman hosts. J Virol. 1992; 66(2):1129-38. PMC: 240817. DOI: 10.1128/JVI.66.2.1129-1138.1992. View

Reid A, Fanning T, HULTIN J, Taubenberger J . Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin gene. Proc Natl Acad Sci U S A. 1999; 96(4):1651-6. PMC: 15547. DOI: 10.1073/pnas.96.4.1651. View

WEIS W, Brown J, Cusack S, Paulson J, Skehel J, Wiley D . Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature. 1988; 333(6172):426-31. DOI: 10.1038/333426a0. View

10.

Taubenberger J, Reid A, Fanning T . The 1918 influenza virus: A killer comes into view. Virology. 2000; 274(2):241-5. DOI: 10.1006/viro.2000.0495. View

11.

Reid A, Taubenberger J . The 1918 flu and other influenza pandemics: "over there" and back again. Lab Invest. 1999; 79(2):95-101. View

12.

Reid A, Taubenberger J, Fanning T . Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus. Nat Rev Microbiol. 2004; 2(11):909-14. PMC: 7097663. DOI: 10.1038/nrmicro1027. View

13.

Reid A, Fanning T, Slemons R, Janczewski T, Dean J, Taubenberger J . Relationship of pre-1918 avian influenza HA and NP sequences to subsequent avian influenza strains. Avian Dis. 2003; 47(3 Suppl):921-5. DOI: 10.1637/0005-2086-47.s3.921. View

14.

Fanning T, Slemons R, Reid A, Janczewski T, Dean J, Taubenberger J . 1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birds. J Virol. 2002; 76(15):7860-2. PMC: 136362. DOI: 10.1128/jvi.76.15.7860-7862.2002. View

15.

Kendal A, Noble G, Skehel J, Dowdle W . Antigenic similarity of influenza A (H1N1) viruses from epidemics in 1977--1978 to "Scandinavian" strains isolated in epidemics of 1950--1951. Virology. 1978; 89(2):632-6. DOI: 10.1016/0042-6822(78)90207-6. View

16.

Basler C, Reid A, Dybing J, Janczewski T, Fanning T, Zheng H . Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proc Natl Acad Sci U S A. 2001; 98(5):2746-51. PMC: 30210. DOI: 10.1073/pnas.031575198. View

17.

Frost W . The epidemiology of influenza. 1919. Public Health Rep. 2006; 121 Suppl 1:149-59. View

18.

Shope R . THE INCIDENCE OF NEUTRALIZING ANTIBODIES FOR SWINE INFLUENZA VIRUS IN THE SERA OF HUMAN BEINGS OF DIFFERENT AGES. J Exp Med. 2009; 63(5):669-84. PMC: 2133359. DOI: 10.1084/jem.63.5.669. View

19.

Simonsen L, Clarke M, Schonberger L, Arden N, Cox N, Fukuda K . Pandemic versus epidemic influenza mortality: a pattern of changing age distribution. J Infect Dis. 1998; 178(1):53-60. DOI: 10.1086/515616. View

20.

Taubenberger J, Reid A, Krafft A, Bijwaard K, Fanning T . Initial genetic characterization of the 1918 "Spanish" influenza virus. Science. 1997; 275(5307):1793-6. DOI: 10.1126/science.275.5307.1793. View