From Stem Cell to Erythroblast: Regulation of Red Cell Production at Multiple Levels by Multiple Hormones

Overview

Journal IUBMB Life

Specialties Biochemistry
Molecular Biology

Date 2010 Mar 23

PMID 20306512

Citations 41

Authors

Harvey Lodish

Johan Flygare

Song Chou

Affiliations

Soon will be listed here.

Abstract

This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU-E progenitors; (2) the regulated expansion of the pool of earlier BFU-E erythroid progenitors by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and (3) the expansion of thehematopoietic cell pool to produce more progenitors of all hematopoietic lineages.

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References

Flygare J, Karlsson S . Diamond-Blackfan anemia: erythropoiesis lost in translation. Blood. 2006; 109(8):3152-4. DOI: 10.1182/blood-2006-09-001222. View

Socolovsky M, Fallon A, Wang S, Brugnara C, Lodish H . Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell. 1999; 98(2):181-91. DOI: 10.1016/s0092-8674(00)81013-2. View

Garrett R, Emerson S . Bone and blood vessels: the hard and the soft of hematopoietic stem cell niches. Cell Stem Cell. 2009; 4(6):503-6. DOI: 10.1016/j.stem.2009.05.011. View

Palis J, Robertson S, Kennedy M, Wall C, Keller G . Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development. 1999; 126(22):5073-84. DOI: 10.1242/dev.126.22.5073. View

Askmyr M, Sims N, Martin T, Purton L . What is the true nature of the osteoblastic hematopoietic stem cell niche?. Trends Endocrinol Metab. 2009; 20(6):303-9. DOI: 10.1016/j.tem.2009.03.004. View

Kiel M, Morrison S . Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol. 2008; 8(4):290-301. DOI: 10.1038/nri2279. View

Zhang J, Lodish H . Endogenous K-ras signaling in erythroid differentiation. Cell Cycle. 2007; 6(16):1970-3. DOI: 10.4161/cc.6.16.4577. View

Wessely O, Deiner E, Beug H, von Lindern M . The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors. EMBO J. 1997; 16(2):267-80. PMC: 1169634. DOI: 10.1093/emboj/16.2.267. View

Sapolsky R, Romero L, Munck A . How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev. 2000; 21(1):55-89. DOI: 10.1210/edrv.21.1.0389. View

10.

Wilson A, Trumpp A . Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol. 2006; 6(2):93-106. DOI: 10.1038/nri1779. View

11.

Socolovsky M, Lodish H, Daley G . Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors. Proc Natl Acad Sci U S A. 1998; 95(12):6573-5. PMC: 33861. DOI: 10.1073/pnas.95.12.6573. View

12.

Elliott S, Pham E, Macdougall I . Erythropoietins: a common mechanism of action. Exp Hematol. 2008; 36(12):1573-84. DOI: 10.1016/j.exphem.2008.08.003. View

13.

Socolovsky M, Nam H, Fleming M, Haase V, Brugnara C, Lodish H . Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood. 2001; 98(12):3261-73. DOI: 10.1182/blood.v98.12.3261. View

14.

Zhang C, Kaba M, Ge G, Xie K, Tong W, Hug C . Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med. 2006; 12(2):240-5. PMC: 2771412. DOI: 10.1038/nm1342. View

15.

Martinez-Agosto J, Mikkola H, Hartenstein V, Banerjee U . The hematopoietic stem cell and its niche: a comparative view. Genes Dev. 2007; 21(23):3044-60. DOI: 10.1101/gad.1602607. View

16.

Dusek T, Kastelan D, Solak M, Basic Kinda S, Aganovic I, Korsic M . Polycythemia as the first manifestation of Cushing's disease. J Endocrinol Invest. 2008; 31(10):940. DOI: 10.1007/BF03346446. View

17.

Eshghi S, Vogelezang M, Hynes R, Griffith L, Lodish H . Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J Cell Biol. 2007; 177(5):871-80. PMC: 2064286. DOI: 10.1083/jcb.200702080. View

18.

Zhang C, Kaba M, Iizuka S, Huynh H, Lodish H . Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood. 2008; 111(7):3415-23. PMC: 2275010. DOI: 10.1182/blood-2007-11-122119. View

19.

Larsson J, Scadden D . Nervous activity in a stem cell niche. Cell. 2006; 124(2):253-5. DOI: 10.1016/j.cell.2006.01.006. View

20.

Adams G, Scadden D . The hematopoietic stem cell in its place. Nat Immunol. 2006; 7(4):333-7. DOI: 10.1038/ni1331. View