Mitotic Force Generators and Chromosome Segregation

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2010 Mar 12

PMID 20221784

Citations 40

Authors

Gul Civelekoglu-Scholey

Jonathan M Scholey

Affiliations

Soon will be listed here.

Abstract

The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-Newton scale forces that are needed to drive the mitotic movements that underlie chromosome capture, alignment and segregation. Here, we consider the biophysical and molecular basis of force-generation for chromosome movements in the spindle, and, with reference to the Drosophila embryo mitotic spindle, we briefly discuss how mathematical modeling can complement experimental analysis to illuminate the mechanisms of chromosome-to-pole motility during anaphase A and spindle elongation during anaphase B.

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