Forensic Implications of Genetic Analyses from Degraded DNA--a Review

Overview

Journal Forensic Sci Int Genet

Publisher Elsevier

Specialties Forensic Sciences
Genetics

Date 2010 Mar 11

PMID 20215026

Citations 64

Authors

Reza Alaeddini

Simon J Walsh

Ali Abbas

Affiliations

Soon will be listed here.

Abstract

Forensic DNA identification techniques are principally based on determination of the size or sequence of desired PCR products. The fragmentation of DNA templates or the structural modifications that can occur during the decomposition process can impact the outcomes of the analytical procedures. This study reviews the pathways involved in cell death and DNA decomposition and the subsequent difficulties these present in DNA analysis of degraded samples.

Citing Articles

A systematic review of associations between the environment, DNA methylation, and cognition.

Glover S, Illyuk J, Hill C, McGuinness B, McKnight A, Hunter R Environ Epigenet. 2025; 11(1):dvae027.

PMID: 39882510 PMC: 11776599. DOI: 10.1093/eep/dvae027.

Analysis of the sequencing quality of next-generation sequencing for the entire mitochondrial genome in decomposed human samples.

Lee S, Kim G, Lee D, Kim H, Kim M Int J Legal Med. 2024; 139(2):551-562.

PMID: 39607452 DOI: 10.1007/s00414-024-03380-3.

SNP Genotype Imputation in Forensics-A Performance Study.

Tillmar A, Kling D Genes (Basel). 2024; 15(11).

PMID: 39596586 PMC: 11593911. DOI: 10.3390/genes15111386.

Genomic Multicopy Loci Targeted by Current Forensic Quantitative PCR Assays.

Jager R Genes (Basel). 2024; 15(10).

PMID: 39457423 PMC: 11507060. DOI: 10.3390/genes15101299.

Age estimation of burnt human remains through DNA methylation analysis.

Grignani P, Bertoglio B, Monti M, Cuoghi Costantini R, Ricci U, Onofri M Int J Legal Med. 2024; 139(1):175-185.

PMID: 39266801 PMC: 11732892. DOI: 10.1007/s00414-024-03320-1.