PARP-1 Val762Ala Polymorphism is Associated with Reduced Risk of Non-Hodgkin Lymphoma in Korean Males

Overview

Journal BMC Med Genet

Publisher Biomed Central

Specialty Genetics

Date 2010 Mar 4

PMID 20196871

Citations 10

Authors

Xue Mei Jin

Hee Nam Kim

Il-Kwon Lee

Kyeong-Soo Park

Hyeoung-Joon Kim

Jin-Su Choi

Sang Woo Juhng

Chan Choi

Affiliations

Soon will be listed here.

Abstract

Background: Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that plays a role in DNA repair, differentiation, proliferation, and cell death. The polymorphisms of PARP-1 have been associated with the risk of various carcinomas, including breast, lung, and prostate. We investigated whether PARP-1 polymorphisms are associated with the risk of non-Hodgkin lymphoma (NHL).

Methods: Subjects from a Korean population consisting of 573 NHL patients and 721 controls were genotyped for 5 PARP-1 polymorphisms (Asp81Asp, Ala284Ala, Lys352Lys, IVS13+118A>G, and Val762Ala) using High Resolution Melting polymerase chain reaction (PCR) and an automatic sequencer.

Results: None of the 5 polymorphisms were associated with overall risk for NHL. However, the Val762Ala polymorphism was associated with reduced risk for NHL in males [odds ratio (OR), 0.62; 95% confidence interval (CI), 0.41-0.93 for CC genotype and OR, 0.84; 95% CI, 0.60-1.16 for TC genotype] with a trend toward a gene dose effect (p for trend, 0.02). The Asp81Asp (p for trend, 0.04) and Lys352Lys (p for trend, 0.03) polymorphisms revealed the same trend. In an association study of PARP-1 haplotypes, the haplotype-ACAAC was associated with decreased risk of NHL in males (OR, 0.75; 95% CI, 0.59-0.94).

Conclusion: The present data suggest that Val762Ala, Asp81Asp, and Lys352Lys polymorphisms and the haplotype-ACAAC in PARP-1 are associated with reduced risk of NHL in Korean males.

Citing Articles

rs1136410 Val762Ala contributes to an increased risk of overall cancer in the East Asian population: a meta-analysis.

Xin Y, Yang L, Su M, Cheng X, Zhu L, Liu J J Int Med Res. 2021; 49(3):300060521992956.

PMID: 33706586 PMC: 8168028. DOI: 10.1177/0300060521992956.

Interaction among susceptibility genotypes of PARP1 SNPs in thyroid carcinoma.

Bashir K, Sarwar R, Saeed S, Mahjabeen I, Kayani M PLoS One. 2018; 13(9):e0199007.

PMID: 30183716 PMC: 6124699. DOI: 10.1371/journal.pone.0199007.

PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies.

Qin Q, Lu J, Zhu H, Xu L, Cheng H, Zhan L PLoS One. 2014; 9(5):e98022.

PMID: 24853559 PMC: 4031170. DOI: 10.1371/journal.pone.0098022.

Association between the PARP1 Val762Ala polymorphism and cancer risk: evidence from 43 studies.

Hua R, Li H, Liang Y, Zhu J, Zhang B, Ye S PLoS One. 2014; 9(1):e87057.

PMID: 24489833 PMC: 3904982. DOI: 10.1371/journal.pone.0087057.

Therapeutic applications of PARP inhibitors: anticancer therapy and beyond.

Curtin N, Szabo C Mol Aspects Med. 2013; 34(6):1217-56.

PMID: 23370117 PMC: 3657315. DOI: 10.1016/j.mam.2013.01.006.

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