Evasion of Apoptosis As a Cellular Stress Response in Cancer

Overview

Journal Int J Cell Biol

Publisher Wiley

Specialty Cell Biology

Date 2010 Feb 26

PMID 20182539

Citations 68

Authors

Simone Fulda

Affiliations

Soon will be listed here.

Abstract

One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis. Evasion of apoptosis can be part of a cellular stress response to ensure the cell's survival upon exposure to stressful stimuli. Apoptosis resistance may contribute to carcinogenesis, tumor progression, and also treatment resistance, since most current anticancer therapies including chemotherapy as well as radio- and immunotherapies primarily act by activating cell death pathways including apoptosis in cancer cells. Hence, a better understanding of the molecular mechanisms regarding how cellular stress stimuli trigger antiapoptotic mechanisms and how this contributes to tumor resistance to apoptotic cell death is expected to provide the basis for a rational approach to overcome apoptosis resistance mechanisms in cancers.

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References

Weston C, Davis R . The JNK signal transduction pathway. Curr Opin Cell Biol. 2007; 19(2):142-9. DOI: 10.1016/j.ceb.2007.02.001. View

Schafer Z, Kornbluth S . The apoptosome: physiological, developmental, and pathological modes of regulation. Dev Cell. 2006; 10(5):549-61. DOI: 10.1016/j.devcel.2006.04.008. View

Willis S, Fletcher J, Kaufmann T, van Delft M, Chen L, Czabotar P . Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science. 2007; 315(5813):856-9. DOI: 10.1126/science.1133289. View

Sturm I, Bosanquet A, Radetzki S, Hummel M, Dorken B, Daniel P . Silencing of APAF-1 in B-CLL results in poor prognosis in the case of concomitant p53 mutation. Int J Cancer. 2005; 118(9):2329-36. DOI: 10.1002/ijc.21535. View

Clement M, Hirpara J, Pervaiz S . Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria. Cell Death Differ. 2003; 10(11):1273-85. DOI: 10.1038/sj.cdd.4401302. View

Roth W, Isenmann S, Nakamura M, Platten M, Wick W, Kleihues P . Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis. Cancer Res. 2001; 61(6):2759-65. View

Holcik M, Lefebvre C, Yeh C, Chow T, Korneluk R . A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection. Nat Cell Biol. 1999; 1(3):190-2. DOI: 10.1038/11109. View

Shiozaki E, Shi Y . Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology. Trends Biochem Sci. 2004; 29(9):486-94. DOI: 10.1016/j.tibs.2004.07.003. View

Friesen C, Fulda S, Debatin K . Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells. Leukemia. 1997; 11(11):1833-41. DOI: 10.1038/sj.leu.2400827. View

10.

Petak I, Danam R, Tillman D, Vernes R, HOWELL S, Berczi L . Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma. Cell Death Differ. 2003; 10(2):211-7. DOI: 10.1038/sj.cdd.4401132. View

11.

Cursi S, Rufini A, Stagni V, Condo I, Matafora V, Bachi A . Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J. 2006; 25(9):1895-905. PMC: 1456929. DOI: 10.1038/sj.emboj.7601085. View

12.

Chen L, Willis S, Wei A, Smith B, Fletcher J, Hinds M . Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005; 17(3):393-403. DOI: 10.1016/j.molcel.2004.12.030. View

13.

Fulda S, Los M, Friesen C, Debatin K . Chemosensitivity of solid tumor cells in vitro is related to activation of the CD95 system. Int J Cancer. 1998; 76(1):105-14. DOI: 10.1002/(sici)1097-0215(19980330)76:1<105::aid-ijc17>3.0.co;2-b. View

14.

Pan Z, Voehringer D, Meyn R . Analysis of redox regulation of cytochrome c-induced apoptosis in a cell-free system. Cell Death Differ. 1999; 6(7):683-8. DOI: 10.1038/sj.cdd.4400544. View

15.

Teitz T, Wei T, Valentine M, Vanin E, Grenet J, Valentine V . Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med. 2000; 6(5):529-35. DOI: 10.1038/75007. View

16.

Degterev A, Boyce M, Yuan J . A decade of caspases. Oncogene. 2003; 22(53):8543-67. DOI: 10.1038/sj.onc.1207107. View

17.

Chen Z, Pervaiz S . BCL-2: pro-or anti-oxidant?. Front Biosci (Elite Ed). 2009; 1(1):263-8. DOI: 10.2741/E25. View

18.

Kroemer G, Galluzzi L, Brenner C . Mitochondrial membrane permeabilization in cell death. Physiol Rev. 2007; 87(1):99-163. DOI: 10.1152/physrev.00013.2006. View

19.

Suto D, Sato K, Ohba Y, Yoshimura T, Fujii J . Suppression of the pro-apoptotic function of cytochrome c by singlet oxygen via a haem redox state-independent mechanism. Biochem J. 2005; 392(Pt 2):399-406. PMC: 1316276. DOI: 10.1042/BJ20050580. View

20.

Kim H, Lee J, Soung Y, Park W, Kim S, Lee J . Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology. 2003; 125(3):708-15. DOI: 10.1016/s0016-5085(03)01059-x. View