Salivary Gland Bioengineering

Overview

Journal Bioengineering (Basel)

Date 2024 Jan 22

PMID 38247905

Authors

Stephen C Rose

Melinda Larsen

Yubing Xie

Susan T Sharfstein

Affiliations

Soon will be listed here.

Abstract

Salivary gland dysfunction affects millions globally, and tissue engineering may provide a promising therapeutic avenue. This review delves into the current state of salivary gland tissue engineering research, starting with a study of normal salivary gland development and function. It discusses the impact of fibrosis and cellular senescence on salivary gland pathologies. A diverse range of cells suitable for tissue engineering including cell lines, primary salivary gland cells, and stem cells are examined. Moreover, the paper explores various supportive biomaterials and scaffold fabrication methodologies that enhance salivary gland cell survival, differentiation, and engraftment. Innovative engineering strategies for the improvement of vascularization, innervation, and engraftment of engineered salivary gland tissue, including bioprinting, microfluidic hydrogels, mesh electronics, and nanoparticles, are also evaluated. This review underscores the promising potential of this research field for the treatment of salivary gland dysfunction and suggests directions for future exploration.

Citing Articles

Unlocking the Future: Bioprinting Salivary Glands-From Possibility to Reality.

Shopova D, Yaneva A, Mihaylova A, Dinkova A, Bakova D J Funct Biomater. 2024; 15(6).

PMID: 38921525 PMC: 11204800. DOI: 10.3390/jfb15060151.

References

Hoebers F, Kartachova M, de Bois J, van den Brekel M, van Tinteren H, Van Herk M . 99mTc Hynic-rh-Annexin V scintigraphy for in vivo imaging of apoptosis in patients with head and neck cancer treated with chemoradiotherapy. Eur J Nucl Med Mol Imaging. 2007; 35(3):509-18. PMC: 2275773. DOI: 10.1007/s00259-007-0624-x. View

Jin H, Zhang Y, Ding Q, Wang S, Rastogi P, Dai D . Epithelial innate immunity mediates tubular cell senescence after kidney injury. JCI Insight. 2019; 4(2). PMC: 6413792. DOI: 10.1172/jci.insight.125490. View

Olivieri F, Rippo M, Monsurro V, Salvioli S, Capri M, Procopio A . MicroRNAs linking inflamm-aging, cellular senescence and cancer. Ageing Res Rev. 2013; 12(4):1056-68. DOI: 10.1016/j.arr.2013.05.001. View

Shubin A, Felong T, Graunke D, Ovitt C, Benoit D . Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications. Tissue Eng Part A. 2015; 21(11-12):1733-51. PMC: 4449707. DOI: 10.1089/ten.TEA.2014.0674. View

Rowlands A, Lim S, Martin D, Cooper-White J . Polyurethane/poly(lactic-co-glycolic) acid composite scaffolds fabricated by thermally induced phase separation. Biomaterials. 2007; 28(12):2109-21. DOI: 10.1016/j.biomaterials.2006.12.032. View

Ramesh P, Moskwa N, Hanchon Z, Koplas A, Nelson D, Mills K . Engineering cryoelectrospun elastin-alginate scaffolds to serve as stromal extracellular matrices. Biofabrication. 2022; 14(3). PMC: 9973022. DOI: 10.1088/1758-5090/ac6b34. View

Amer M, Rose F, Shakesheff K, Modo M, White L . Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges. NPJ Regen Med. 2018; 2:23. PMC: 5677964. DOI: 10.1038/s41536-017-0028-x. View

Andrade L, Rodrigues C, Gomes S, Noronha I . Acute Kidney Injury as a Condition of Renal Senescence. Cell Transplant. 2018; 27(5):739-753. PMC: 6047270. DOI: 10.1177/0963689717743512. View

Aguado B, Mulyasasmita W, Su J, Lampe K, Heilshorn S . Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers. Tissue Eng Part A. 2011; 18(7-8):806-15. PMC: 3313609. DOI: 10.1089/ten.TEA.2011.0391. View

10.

Robar J, Day A, Clancey J, Kelly R, Yewondwossen M, Hollenhorst H . Spatial and dosimetric variability of organs at risk in head-and-neck intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2007; 68(4):1121-30. DOI: 10.1016/j.ijrobp.2007.01.030. View

11.

Hauser B, Aure M, Kelly M, Hoffman M, Chibly A . Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland Development. iScience. 2020; 23(12):101838. PMC: 7718488. DOI: 10.1016/j.isci.2020.101838. View

12.

McCarthy D, Clark R, Bartling T, Trebak M, Melendez J . Redox control of the senescence regulator interleukin-1α and the secretory phenotype. J Biol Chem. 2013; 288(45):32149-32159. PMC: 3820855. DOI: 10.1074/jbc.M113.493841. View

13.

Miyake Y, Shimizu O, Shiratsuchi H, Tamagawa T, Tonogi M . Wound healing after applying a gelatin-based hydrogel sheet to resected rat submandibular gland. J Oral Sci. 2020; 62(2):222-225. DOI: 10.2334/josnusd.19-0244. View

14.

Ozdemir T, Fowler E, Hao Y, Ravikrishnan A, Harrington D, Witt R . Biomaterials-based strategies for salivary gland tissue regeneration. Biomater Sci. 2016; 4(4):592-604. PMC: 4803517. DOI: 10.1039/c5bm00358j. View

15.

Aframian D, Cukierman E, Nikolovski J, Mooney D, Yamada K, Baum B . The growth and morphological behavior of salivary epithelial cells on matrix protein-coated biodegradable substrata. Tissue Eng. 2000; 6(3):209-16. DOI: 10.1089/10763270050044380. View

16.

Lindroos B, Suuronen R, Miettinen S . The potential of adipose stem cells in regenerative medicine. Stem Cell Rev Rep. 2010; 7(2):269-91. DOI: 10.1007/s12015-010-9193-7. View

17.

Yamada A, Futagi M, Fukumoto E, Saito K, Yoshizaki K, Ishikawa M . Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation. J Biol Chem. 2015; 291(2):904-12. PMC: 4705408. DOI: 10.1074/jbc.M115.674663. View

18.

Stone G, Ellis S, Cox D, Hermiller J, OShaughnessy C, Mann J . A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med. 2004; 350(3):221-31. DOI: 10.1056/NEJMoa032441. View

19.

Plow E, Haas T, Zhang L, Loftus J, Smith J . Ligand binding to integrins. J Biol Chem. 2000; 275(29):21785-8. DOI: 10.1074/jbc.R000003200. View

20.

Jean-Gilles R, Soscia D, Sequeira S, Melfi M, Gadre A, Castracane J . Novel Modeling Approach to Generate a Polymeric Nanofiber Scaffold for Salivary Gland Cells. J Nanotechnol Eng Med. 2012; 1(3):31008. PMC: 3252387. DOI: 10.1115/1.4001744. View