» Articles » PMID: 20166810

Adipose Tissue Engineering for Soft Tissue Regeneration

Overview
Date 2010 Feb 20
PMID 20166810
Citations 77
Authors
Affiliations
Soon will be listed here.
Abstract

Current treatment modalities for soft tissue defects caused by various pathologies and trauma include autologous grafting and commercially available fillers. However, these treatment methods present a number of challenges and limitations, such as donor-site morbidity and volume loss over time. As such, improved therapeutic modalities need to be developed. Tissue engineering techniques offer novel solutions to these problems through development of bioactive tissue constructs that can regenerate adipose tissue in both structure and function. Recently, a number of studies have been designed to explore various methods to engineer human adipose tissue. This review will focus on these developments in the area of adipose tissue engineering for soft tissue replacement. The physiology of adipose tissue and current surgical therapies used to replace lost tissue volume, specifically in breast tissue, are introduced, and current biomaterials, cell sources, and tissue culture strategies are discussed. We discuss future areas of study in adipose tissue engineering.

Citing Articles

Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue.

Lee S, Lee J, Kwon H, Shin H Bioact Mater. 2025; 48:171-188.

PMID: 40046010 PMC: 11880769. DOI: 10.1016/j.bioactmat.2025.02.024.


Adipogenic dedifferentiation enhances survival of human umbilical cord-derived mesenchymal stem cells under oxidative stress.

Yuan Y, Kuang M, Yu T, Huang S, Jiang F, Lu B Adipocyte. 2025; 14(1):2467150.

PMID: 39976240 PMC: 11845070. DOI: 10.1080/21623945.2025.2467150.


Adipogenesis of bioabsorbable implants under irradiation in a rodent model.

Lee S, Ogino S, Inoue M, Nakano T, Kato Y, Sakamoto M Regen Ther. 2024; 26:990-998.

PMID: 39524181 PMC: 11550574. DOI: 10.1016/j.reth.2024.10.002.


Exploring Morphological and Molecular Properties of Different Adipose Cell Models: Monolayer, Spheroids, Gellan Gum-Based Hydrogels, and Explants.

Albrecht F, Schick A, Klatt A, Schmidt F, Nellinger S, Kluger P Macromol Biosci. 2024; 25(3):e2400320.

PMID: 39450850 PMC: 11904394. DOI: 10.1002/mabi.202400320.


Minimally invasive soft tissue repair using shrunken scaffolds.

Xie M, Jin S, Yu K, Lin H, He Y Nat Commun. 2024; 15(1):6739.

PMID: 39112538 PMC: 11306247. DOI: 10.1038/s41467-024-51248-2.


References
1.
Lai N, Jayaraman A, Lee K . Enhanced proliferation of human umbilical vein endothelial cells and differentiation of 3T3-L1 adipocytes in coculture. Tissue Eng Part A. 2008; 15(5):1053-61. PMC: 2767334. DOI: 10.1089/ten.tea.2008.0101. View

2.
Dubois S, Floyd E, Zvonic S, Kilroy G, Wu X, Carling S . Isolation of human adipose-derived stem cells from biopsies and liposuction specimens. Methods Mol Biol. 2008; 449:69-79. DOI: 10.1007/978-1-60327-169-1_5. View

3.
Schipper B, Marra K, Zhang W, Donnenberg A, Rubin J . Regional anatomic and age effects on cell function of human adipose-derived stem cells. Ann Plast Surg. 2008; 60(5):538-44. PMC: 4160894. DOI: 10.1097/SAP.0b013e3181723bbe. View

4.
Alhadlaq A, Tang M, Mao J . Engineered adipose tissue from human mesenchymal stem cells maintains predefined shape and dimension: implications in soft tissue augmentation and reconstruction. Tissue Eng. 2005; 11(3-4):556-66. DOI: 10.1089/ten.2005.11.556. View

5.
Altman G, Diaz F, Jakuba C, Calabro T, Horan R, Chen J . Silk-based biomaterials. Biomaterials. 2002; 24(3):401-16. DOI: 10.1016/s0142-9612(02)00353-8. View