An Amine-derivatized, DOTA-loaded Polymeric Support for Fmoc Solid Phase Peptide Synthesis

Overview

Journal Tetrahedron Lett

Publisher Elsevier

Specialty Chemistry

Date 2010 Feb 18

PMID 20161272

Citations 15

Authors

Byunghee Yoo

Vipul R Sheth

Mark D Pagel

Affiliations

Soon will be listed here.

Abstract

An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.

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