Diverted Total Synthesis Leads to the Generation of Promising Cell-migration Inhibitors for Treatment of Tumor Metastasis: in Vivo and Mechanistic Studies on the Migrastatin Core Ether Analog

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2010 Feb 17

PMID 20155906

Citations 17

Authors

Thordur Oskarsson

Pavel Nagorny

Isaac J Krauss

Lucy Perez

Mihirbaran Mandal

Guangli Yang

Ouathek Ouerfelli

Danhua Xiao

Malcolm A S Moore

Joan Massague

Samuel J Danishefsky

Affiliations

Soon will be listed here.

Abstract

A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.

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