Synthesis and Characterization of a Novel INOS/Akt Inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against Colon Cancer

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2010 Feb 16

PMID 20153642

Citations 8

Authors

Dhimant Desai

SubbaRao V Madhunapantula

Krishnegowda Gowdahalli

Arati Sharma

Raghavendragowda Chandagaludoreswamy

Karam El-Bayoumy

Gavin P Robertson

Shantu Amin

Affiliations

Soon will be listed here.

Abstract

Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.

Citing Articles

A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer.

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Microwave-assisted synthesis of new selenazole derivatives with antiproliferative activity.

Ignat Grozav A, Gaina L, Kuete V, Silaghi-Dumitrescu L, Efferth T, Zaharia V Molecules. 2013; 18(4):4679-88.

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Chemoprevention of melanoma.

Madhunapantula S, Robertson G Adv Pharmacol. 2012; 65:361-98.

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The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.

Madhunapantula S, Mosca P, Robertson G Cancer Biol Ther. 2011; 12(12):1032-49.

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Melanoma prevention using topical PBISe.

Chung C, Madhunapantula S, Desai D, Amin S, Robertson G Cancer Prev Res (Phila). 2011; 4(6):935-48.

PMID: 21367959 PMC: 3493621. DOI: 10.1158/1940-6207.CAPR-10-0202.

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