Inferring the Functions of Longevity Genes with Modular Subnetwork Biomarkers of Caenorhabditis Elegans Aging

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2010 Feb 5

PMID 20128910

Citations 16

Authors

Kristen Fortney

Max Kotlyar

Igor Jurisica

Affiliations

Soon will be listed here.

Abstract

A central goal of biogerontology is to identify robust gene-expression biomarkers of aging. Here we develop a method where the biomarkers are networks of genes selected based on age-dependent activity and a graph-theoretic property called modularity. Tested on Caenorhabditis elegans, our algorithm yields better biomarkers than previous methods - they are more conserved across studies and better predictors of age. We apply these modular biomarkers to assign novel aging-related functions to poorly characterized longevity genes.

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