Integrative Approaches for Finding Modular Structure in Biological Networks

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2013 Sep 19

PMID 24045689

Citations 244

Authors

Koyel Mitra

Anne-Ruxandra Carvunis

Sanath Kumar Ramesh

Trey Ideker

Affiliations

Soon will be listed here.

Abstract

A central goal of systems biology is to elucidate the structural and functional architecture of the cell. To this end, large and complex networks of molecular interactions are being rapidly generated for humans and model organisms. A recent focus of bioinformatics research has been to integrate these networks with each other and with diverse molecular profiles to identify sets of molecules and interactions that participate in a common biological function - that is, 'modules'. Here, we classify such integrative approaches into four broad categories, describe their bioinformatic principles and review their applications.

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