Potential of Creatine Supplementation for Improving Aging Bone Health
Overview
Nutritional Sciences
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Aging subsequently results in bone and muscle loss which has a negative effect on strength, agility, and balance leading to increased risks of falls, injuries, and fractures. Resistance training is an effective strategy for maintaining bone mass, possibly by increasing activity of cells involved in bone formation and reducing activity of cells involved in bone resorption. However, bone loss is still evident in older adults who have maintained resistance training for most of their life, suggesting that other factors such as nutrition may be involved in the aging bone process. Emerging evidence suggests that creatine supplementation, with and without resistance training, has the potential to influence bone biology. However, research investigating the longer-term effects of creatine supplementation and resistance training on aging bone is limited.
Baltic S, Nedeljkovic D, Todorovic N, Ratgeber L, Betlehem J, Acs P J Nutr Metab. 2024; 2024:7815807.
PMID: 39434888 PMC: 11493483. DOI: 10.1155/2024/7815807.
Creatine in Health and Disease.
Kreider R, Stout J Nutrients. 2021; 13(2).
PMID: 33572884 PMC: 7910963. DOI: 10.3390/nu13020447.
Nutritional Considerations and Strategies to Facilitate Injury Recovery and Rehabilitation.
Smith-Ryan A, Hirsch K, Saylor H, Gould L, Blue M J Athl Train. 2020; 55(9):918-930.
PMID: 32991705 PMC: 7534941. DOI: 10.4085/1062-6050-550-19.
Kulczynski B, Sidor A, Gramza-Michalowska A Antioxidants (Basel). 2019; 8(9).
PMID: 31443517 PMC: 6769838. DOI: 10.3390/antiox8090335.
Assessing the Associations of Blood Metabolites With Osteoporosis: A Mendelian Randomization Study.
Liu L, Wen Y, Zhang L, Xu P, Liang X, Du Y J Clin Endocrinol Metab. 2018; 103(5):1850-1855.
PMID: 29506141 PMC: 6456956. DOI: 10.1210/jc.2017-01719.