Serine Racemase Deletion Protects Against Cerebral Ischemia and Excitotoxicity

Overview

Journal J Neurosci

Specialty Neurology

Date 2010 Jan 29

PMID 20107067

Citations 41

Authors

Asif K Mustafa

Abdullah S Ahmad

Emil Zeynalov

Sadia K Gazi

Gautam Sikka

Jeffrey T Ehmsen

Roxanne K Barrow

Joseph T Coyle

Solomon H Snyder

Sylvain Dore

Affiliations

Soon will be listed here.

Abstract

D-Serine, formed from L-serine by serine racemase (SR), is a physiologic coagonist at NMDA receptors. Using mice with targeted deletion of SR, we demonstrate a role for D-serine in NMDA receptor-mediated neurotoxicity and stroke. Brain cultures of SR-deleted mice display markedly diminished nitric oxide (NO) formation and neurotoxicity. In intact SR knock-out mice, NO formation and nitrosylation of NO targets are substantially reduced. Infarct volume following middle cerebral artery occlusion is dramatically diminished in several regions of the brains of SR mutant mice despite evidence of increased NMDA receptor number and sensitivity.

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