Protein S-nitrosylation: Purview and Parameters

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2005 Feb 3

PMID 15688001

Citations 872

Authors

Douglas T Hess

Akio Matsumoto

Sung-Oog Kim

Harvey E Marshall

Jonathan S Stamler

Affiliations

Soon will be listed here.

Abstract

S-nitrosylation, the covalent attachment of a nitrogen monoxide group to the thiol side chain of cysteine, has emerged as an important mechanism for dynamic, post-translational regulation of most or all main classes of protein. S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation.

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