Joseph T Coyle
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Explore the profile of Joseph T Coyle including associated specialties, affiliations and a list of published articles.
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128
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4492
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Recent Articles
1.
Kambali M, Li Y, Unichenko P, Feria Pliego J, Yadav R, Liu J, et al.
Mol Psychiatry
. 2024 Aug;
30(3):927-942.
PMID: 39210012
Glycine is an obligatory co-agonist at excitatory NMDA receptors in the brain, especially in the dentate gyrus, which has been postulated to be crucial for the development of psychotic associations...
2.
Yu I, Coyle J, Desai R
Nicotine Tob Res
. 2024 Jun;
26(12):1744-1748.
PMID: 38919117
Introduction: The high comorbidity between schizophrenia and cigarette smoking points to a possible shared heritable factor predisposing individuals with schizophrenia to nicotine addiction. The N-methyl-d-aspartate (NMDA) receptor has been highly...
3.
Coyle J
Biochem Pharmacol
. 2024 Jun;
228:116376.
PMID: 38906225
For nearly fifty years, the dopamine hypothesis has dominated our understanding of the pathophysiology of schizophrenia and provided the lone target for drug development. However, with the exception of clozapine,...
4.
Kambali M, Li Y, Unichenko P, Pliego J, Yadav R, Liu J, et al.
bioRxiv
. 2023 Jul;
PMID: 37398055
The biological significance of a small supernumerary marker chromosome that results in dosage alterations to chromosome 9p24.1, including triplication of the gene encoding glycine decarboxylase, in two patients with psychosis...
5.
Liu D, Zinski A, Mishra A, Noh H, Park G, Qin Y, et al.
Mol Psychiatry
. 2022 Jun;
27(10):4218-4233.
PMID: 35701597
Remarkable advances have been made in schizophrenia (SCZ) GWAS, but gleaning biological insight from these loci is challenging. Genetic influences on gene expression (e.g., eQTLs) are cell type-specific, but most...
6.
Nomoto M, Konopaske G, Yamashita N, Aoki R, Jitsuki-Takahashi A, Nakamura H, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(31).
PMID: 34330827
There are no validated biomarkers for schizophrenia (SCZ), a disorder linked to neural network dysfunction. We demonstrate that collapsin response mediator protein-2 (CRMP2), a master regulator of cytoskeleton and, hence,...
7.
Dallerac G, Li X, Lecouflet P, Morisot N, Sacchi S, Asselot R, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(23).
PMID: 34083436
Prefrontal control of cognitive functions critically depends upon glutamatergic transmission and N-methyl D-aspartate (NMDA) receptors, the activity of which is regulated by dopamine. Yet whether the NMDA receptor coagonist d-serine...
8.
Aguilar D, Radzik L, Schiffino F, Folorunso O, Zielinski M, Coyle J, et al.
Sci Rep
. 2021 Apr;
11(1):9031.
PMID: 33907230
Abnormalities in electroencephalographic (EEG) biomarkers occur in patients with schizophrenia and those clinically at high risk for transition to psychosis and are associated with cognitive impairment. Converging evidence suggests N-methyl-D-aspartate...
9.
Coyle J, Ruzicka W, Balu D
Am J Psychiatry
. 2020 Dec;
177(12):1119-1128.
PMID: 33256439
No abstract available.
10.
Takagi S, Balu D, Coyle J
Brain Res
. 2020 Nov;
1751:147202.
PMID: 33171153
d-Serine plays an important role in modulating N-methyl-d-aspartate receptor (NMDAR) neurotransmission in the mammalian brain by binding to the receptor's glycine modulatory site (GMS). The cytosolic enzyme serine racemase (SR)...