Dietary Hesperidin Exerts Hypoglycemic and Hypolipidemic Effects in Streptozotocin-induced Marginal Type 1 Diabetic Rats

Overview

Journal J Clin Biochem Nutr

Specialty Biochemistry

Date 2010 Jan 28

PMID 20104270

Citations 55

Authors

Satoko Akiyama

Shin-Ichi Katsumata

Kazuharu Suzuki

Yoshiko Ishimi

Jian Wu

Mariko Uehara

Affiliations

Soon will be listed here.

Abstract

Citrus bioflavonoids may offer some protection against the early stage of diabetes mellitus and the development of complications. We investigated the effect of hesperidin on blood glucose levels, hepatic glucose-regulating enzyme activities, serum insulin and adiponectin levels, serum and hepatic lipid levels, and parameters of bone loss in streptozotocin (STZ)-induced marginal type 1 diabetic rats. Weanling male rats were randomly assigned to experimental 3 groups: a control (C) group, a STZ induced marginal type 1 diabetes (S) group, and a diabetes and hesperidin group, and fed their respective diets for 4 weeks. STZ injection increased blood glucose in rats, but the increase was marginal. Serum and hepatic lipids, serum adiponectin and insulin levels were significantly changed by STZ injection. Dietary hesperidin (10 g/kg diet) decreased blood glucose by altering the activity of glucose-regulating enzymes, and normalized the lipids and adiponectin levels, but did not change bone parameters in the marginal type 1 diabetic rats. Hesperidin showed both hypoglycemic and hypolipidemic effects but did not affect bone tissue and bone metabolic makers in STZ-injected marginal diabetic weanling rats without any body weight loss due to STZ injection.

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