Clinical Applications and Mechanism Insights of Natural Flavonoids Against Type 2 Diabetes Mellitus

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 May 2

PMID 38694079

Authors

Abdelhakim Bouyahya

Abdelaali Balahbib

Asaad Khalid

Hafiz A Makeen

Hassan A Alhazmi

Mohammed Albratty

Andi Hermansyah

Long Chiau Ming

Khang Wen Goh

Nasreddine El Omari

Affiliations

Soon will be listed here.

Abstract

Diabetes is a complex disease that affects a large percentage of the world's population, and it is associated with several risk factors. Self-management poses a significant challenge, but natural sources have shown great potential in providing effective glucose reducing solutions. Flavonoids, a class of bioactive substances found in different natural sources including medicinal plants, have emerged as promising candidates in this regard. Indeed, several flavonoids, including apigenin, arbutin, catechins, and cyanidin, have demonstrated remarkable anti-diabetic properties. The clinical effectiveness of these flavonoids is linked to their potential to decrease blood glucose concentration and increase insulin concentration. Thus, the regulation of certain metabolic pathways such as glycolysis and neoglycogenesis has also been demonstrated. and investigations revealed different mechanisms of action related to flavonoid compounds at subcellular, cellular, and molecular levels. The main actions reside in the activation of glycolytic signaling pathways and the inhibition of signaling that promotes glucose synthesis and storage. In this review, we highlight the clinical efficiency of natural flavonoids as well as the molecular mechanisms underlying this effectiveness.

Citing Articles

Immunomodulation of Macrophages in Diabetic Wound Individuals by Structurally Diverse Bioactive Phytochemicals.

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PMID: 39458935 PMC: 11510503. DOI: 10.3390/ph17101294.

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