Maternal Dietary Glycemic Intake and the Risk of Neural Tube Defects

Overview

Journal Am J Epidemiol

Publisher Oxford University Press

Specialty Public Health

Date 2010 Jan 1

PMID 20042435

Citations 27

Authors

Mahsa M Yazdy

Simin Liu

Allen A Mitchell

Martha M Werler

Affiliations

Soon will be listed here.

Abstract

Both maternal diabetes and obesity have been associated with an increased risk of neural tube defects (NTD), possibly due to a sustained state of hyperglycemia and/or hyperinsulinemia. Data were collected in the Boston University Slone Birth Defects Study (a case-control study) from 1988 to 1998. The authors examined whether high dietary glycemic index (DGI) and high dietary glycemic load (DGL) increased the risk of NTDs in nondiabetic women. Mothers of NTD cases and nonmalformed controls were interviewed in person within 6 months after delivery about diet and other exposures. Odds ratios and 95% confidence intervals were estimated from logistic regression for high DGI (> or =60) and high DGL (> or =205), with cutpoints determined by cubic spline. Of 698 case mothers, 25% had high DGI and 4% had high DGL. Of 696 control mothers, 15% had high DGI and 2% had high DGL. After adjustment for sociodemographic factors and other dietary factors, the odds ratio for high DGI was 1.5 (95% confidence interval: 1.1, 2.0); for high DGL, it was 1.8 (95% confidence interval: 0.8, 4.0). Diets with proportionally high DGI or DGL may put the developing fetus at risk of an NTD, adding further evidence that hyperglycemia lies within the pathogenic pathway.

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References

Willett W, Manson J, Liu S . Glycemic index, glycemic load, and risk of type 2 diabetes. Am J Clin Nutr. 2002; 76(1):274S-80S. DOI: 10.1093/ajcn/76/1.274S. View

Werler M, Louik C, Shapiro S, Mitchell A . Prepregnant weight in relation to risk of neural tube defects. JAMA. 1996; 275(14):1089-92. DOI: 10.1001/jama.1996.03530380031027. View

Mokdad A, Serdula M, Dietz W, Bowman B, Marks J, Koplan J . The spread of the obesity epidemic in the United States, 1991-1998. JAMA. 1999; 282(16):1519-22. DOI: 10.1001/jama.282.16.1519. View

Feig D, Palda V . Type 2 diabetes in pregnancy: a growing concern. Lancet. 2002; 359(9318):1690-2. DOI: 10.1016/S0140-6736(02)08599-9. View

Waller D, Mills J, Simpson J, Cunningham G, Conley M, Lassman M . Are obese women at higher risk for producing malformed offspring?. Am J Obstet Gynecol. 1994; 170(2):541-8. DOI: 10.1016/s0002-9378(94)70224-1. View

Ramos-Arroyo M, Rodriguez-Pinilla E, Cordero J . Maternal diabetes: the risk for specific birth defects. Eur J Epidemiol. 1992; 8(4):503-8. DOI: 10.1007/BF00146367. View

Boegner C, Bringer J . Obesity and pregnancy: complications and cost. Am J Clin Nutr. 2000; 71(5 Suppl):1242S-8S. DOI: 10.1093/ajcn/71.5.1242s. View

Hendricks K, Nuno O, Suarez L, Larsen R . Effects of hyperinsulinemia and obesity on risk of neural tube defects among Mexican Americans. Epidemiology. 2001; 12(6):630-5. DOI: 10.1097/00001648-200111000-00009. View

Kallen K . Maternal smoking, body mass index, and neural tube defects. Am J Epidemiol. 1998; 147(12):1103-11. DOI: 10.1093/oxfordjournals.aje.a009408. View

10.

Liu S, Manson J, Stampfer M, Holmes M, Hu F, Hankinson S . Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal women. Am J Clin Nutr. 2001; 73(3):560-6. DOI: 10.1093/ajcn/73.3.560. View

11.

Shaw G, Quach T, Nelson V, Carmichael S, Schaffer D, Selvin S . Neural tube defects associated with maternal periconceptional dietary intake of simple sugars and glycemic index. Am J Clin Nutr. 2003; 78(5):972-8. DOI: 10.1093/ajcn/78.5.972. View

12.

Watkins M, Rasmussen S, Honein M, Botto L, Moore C . Maternal obesity and risk for birth defects. Pediatrics. 2003; 111(5 Pt 2):1152-8. View

13.

Janssen P, Rothman I, Schwartz S . Congenital malformations in newborns of women with established and gestational diabetes in Washington State, 1984-91. Paediatr Perinat Epidemiol. 1996; 10(1):52-63. DOI: 10.1111/j.1365-3016.1996.tb00026.x. View

14.

Rowland C, Correa A, Cragan J, Alverson C . Are encephaloceles neural tube defects?. Pediatrics. 2006; 118(3):916-23. DOI: 10.1542/peds.2005-1739. View

15.

Beemster P, Groenen P, Steegers-Theunissen R . Involvement of inositol in reproduction. Nutr Rev. 2002; 60(3):80-7. DOI: 10.1301/00296640260042748. View

16.

WATKINS M, Edmonds L, McClearn A, MULLINS L, Mulinare J, Khoury M . The surveillance of birth defects: the usefulness of the revised US standard birth certificate. Am J Public Health. 1996; 86(5):731-4. PMC: 1380486. DOI: 10.2105/ajph.86.5.731. View

17.

Reece E, Homko C, Wu Y . Multifactorial basis of the syndrome of diabetic embryopathy. Teratology. 1996; 54(4):171-82. DOI: 10.1002/(SICI)1096-9926(199610)54:4<171::AID-TERA1>3.0.CO;2-4. View

18.

Shaw G, Carmichael S, Laurent C, Siega-Riz A . Periconceptional glycaemic load and intake of sugars and their association with neural tube defects in offspring. Paediatr Perinat Epidemiol. 2008; 22(6):514-9. DOI: 10.1111/j.1365-3016.2008.00964.x. View

19.

Mokdad A, Ford E, Bowman B, Nelson D, Engelgau M, Vinicor F . Diabetes trends in the U.S.: 1990-1998. Diabetes Care. 2000; 23(9):1278-83. DOI: 10.2337/diacare.23.9.1278. View

20.

Braam L, Ocke M, Bueno-de-Mesquita H, Seidell J . Determinants of obesity-related underreporting of energy intake. Am J Epidemiol. 1998; 147(11):1081-6. DOI: 10.1093/oxfordjournals.aje.a009402. View