Dietary Glycemic Index and the Risk of Birth Defects

Overview

Journal Am J Epidemiol

Publisher Oxford University Press

Specialty Public Health

Date 2012 Nov 23

PMID 23171874

Citations 8

Authors

Samantha E Parker

Martha M Werler

Gary M Shaw

Marlene Anderka

Mahsa M Yazdy

Affiliations

Soon will be listed here.

Abstract

Prepregnancy diabetes and obesity have been identified as independent risk factors for several birth defects, providing support for a mechanism that involves hyperglycemia and hyperinsulinemia in the development of malformations. Data from the National Birth Defects Prevention Study from 1997 to 2007 were used to investigate the association between the maternal dietary glycemic index (DGI) and the risk of birth defects among nondiabetic women. DGI was categorized by using spline regression models and quartile distributions. Adjusted odds ratios and 95% confidence intervals were calculated. The joint effect of DGI and obesity was also examined. Among the 53 birth defects analyzed, high DGI, categorized by spline regression, was significantly associated with encephalocele (adjusted odds ratio (aOR) = 2.68), diaphragmatic hernia (aOR = 2.58), small intestinal atresia/stenosis (aOR = 2.97) including duodenal atresia/stenosis (aOR = 2.48), and atrial septal defect (aOR = 1.37). Using quartiles to categorize DGI, the authors identified associations with cleft lip with cleft palate (aOR = 1.23) and anorectal atresia/stenosis (aOR = 1.40). The joint effect of high DGI and obesity provided evidence of a synergistic effect on the risk of selected birth defects. High DGI is associated with an increased risk of a number of birth defects under study. Obesity coupled with high DGI appears to increase the risk further for some birth defects.

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References

Lam P, Torfs C, Brand R . A low pregnancy body mass index is a risk factor for an offspring with gastroschisis. Epidemiology. 1999; 10(6):717-21. View

McLaughlin T, Allison G, Abbasi F, Lamendola C, Reaven G . Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals. Metabolism. 2004; 53(4):495-9. DOI: 10.1016/j.metabol.2003.10.032. View

Yoon P, Rasmussen S, Lynberg M, Moore C, Anderka M, Carmichael S . The National Birth Defects Prevention Study. Public Health Rep. 2002; 116 Suppl 1:32-40. PMC: 1913684. DOI: 10.1093/phr/116.S1.32. View

Dunne F, Brydon P, Smith K, Gee H . Pregnancy in women with Type 2 diabetes: 12 years outcome data 1990-2002. Diabet Med. 2003; 20(9):734-8. DOI: 10.1046/j.1464-5491.2003.01017.x. View

Anderson J, Waller D, Canfield M, Shaw G, Watkins M, Werler M . Maternal obesity, gestational diabetes, and central nervous system birth defects. Epidemiology. 2004; 16(1):87-92. DOI: 10.1097/01.ede.0000147122.97061.bb. View

Moore L, Singer M, Bradlee M, Rothman K, Milunsky A . A prospective study of the risk of congenital defects associated with maternal obesity and diabetes mellitus. Epidemiology. 2000; 11(6):689-94. DOI: 10.1097/00001648-200011000-00013. View

Carmichael S, Yang W, Shaw G . Periconceptional nutrient intakes and risks of neural tube defects in California. Birth Defects Res A Clin Mol Teratol. 2010; 88(8):670-8. PMC: 2929981. DOI: 10.1002/bdra.20675. View

Fuhrmann K, REIHER H, Semmler K, Fischer F, Fischer M, Glockner E . Prevention of congenital malformations in infants of insulin-dependent diabetic mothers. Diabetes Care. 1983; 6(3):219-23. DOI: 10.2337/diacare.6.3.219. View

Yazdy M, Liu S, Mitchell A, Werler M . Maternal dietary glycemic intake and the risk of neural tube defects. Am J Epidemiol. 2010; 171(4):407-14. PMC: 2842193. DOI: 10.1093/aje/kwp395. View

10.

Waller D, Shaw G, Rasmussen S, Hobbs C, Canfield M, Siega-Riz A . Prepregnancy obesity as a risk factor for structural birth defects. Arch Pediatr Adolesc Med. 2007; 161(8):745-50. DOI: 10.1001/archpedi.161.8.745. View

11.

Hendricks K, Nuno O, Suarez L, Larsen R . Effects of hyperinsulinemia and obesity on risk of neural tube defects among Mexican Americans. Epidemiology. 2001; 12(6):630-5. DOI: 10.1097/00001648-200111000-00009. View

12.

Correa A, Gilboa S, Besser L, Botto L, Moore C, Hobbs C . Diabetes mellitus and birth defects. Am J Obstet Gynecol. 2008; 199(3):237.e1-9. PMC: 4916956. DOI: 10.1016/j.ajog.2008.06.028. View

13.

Shaw G, Quach T, Nelson V, Carmichael S, Schaffer D, Selvin S . Neural tube defects associated with maternal periconceptional dietary intake of simple sugars and glycemic index. Am J Clin Nutr. 2003; 78(5):972-8. DOI: 10.1093/ajcn/78.5.972. View

14.

Watkins M, Rasmussen S, Honein M, Botto L, Moore C . Maternal obesity and risk for birth defects. Pediatrics. 2003; 111(5 Pt 2):1152-8. View

15.

Temple R, Aldridge V, Murphy H . Prepregnancy care and pregnancy outcomes in women with type 1 diabetes. Diabetes Care. 2006; 29(8):1744-9. DOI: 10.2337/dc05-2265. View

16.

Willett W, Manson J, Liu S . Glycemic index, glycemic load, and risk of type 2 diabetes. Am J Clin Nutr. 2002; 76(1):274S-80S. DOI: 10.1093/ajcn/76/1.274S. View

17.

Shaw G, Carmichael S, Laurent C, Siega-Riz A . Periconceptional glycaemic load and intake of sugars and their association with neural tube defects in offspring. Paediatr Perinat Epidemiol. 2008; 22(6):514-9. DOI: 10.1111/j.1365-3016.2008.00964.x. View

18.

Barclay A, Flood V, Brand-Miller J, Mitchell P . Validity of carbohydrate, glycaemic index and glycaemic load data obtained using a semi-quantitative food-frequency questionnaire. Public Health Nutr. 2007; 11(6):573-80. DOI: 10.1017/S1368980007001103. View

19.

Gilboa S, Correa A, Botto L, Rasmussen S, Waller D, Hobbs C . Association between prepregnancy body mass index and congenital heart defects. Am J Obstet Gynecol. 2009; 202(1):51.e1-51.e10. DOI: 10.1016/j.ajog.2009.08.005. View

20.

Braam L, Ocke M, Bueno-de-Mesquita H, Seidell J . Determinants of obesity-related underreporting of energy intake. Am J Epidemiol. 1998; 147(11):1081-6. DOI: 10.1093/oxfordjournals.aje.a009402. View