Sphingosine-1-phosphate: a Potential Therapeutic Agent Against Human Breast Cancer

Overview

Journal Invest New Drugs

Publisher Springer

Specialty Oncology

Date 2009 Dec 31

PMID 20041340

Citations 8

Authors

Binbing Ling

Lifeng Chen

Jane Alcorn

Baohua Ma

Jian Yang

Affiliations

Soon will be listed here.

Abstract

Sphingosine-1-phosphate (S1P) is an important regulator of cancer development and progression. Its cellular concentration is controlled predominantly by sphingosine kinase (SK) and sphingosine-1-phosphate lyase (SPL). In the current study we showed that mRNA expressions for both SK and SPL were up-regulated throughout all four disease stages in human breast cancer patients. Exogenous administration of S1P produced a bell-shaped dose response for apoptosis in normal mammary gland MCF12A cells but a sigmoid-shaped apoptotic response in breast cancer MCF7 cells. Co-administration of S1P enhanced the cytotoxicity of anticancer drug docetaxel against MCF7 cells.

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