Effects of New Endogenous Nonprotein Amino Acids, 1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid Derivatives, on Behavior of Mice
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Several 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids were synthesized and found to have a transiently increasing effect on the locomotor activity of mice after peripheral injection. Three of the active compounds were detected in the brain after intraperitoneal administration. Two of them, the 7-hydroxy and 7-hydroxy-6-methoxy derivatives, were found as endogenous compounds in untreated rat brain and may play a physiological role. The effects of some of these compounds on the level of various endogenous amines, amino acids and metabolites were examined.
Wang X, Zhan E, Lu G, Mu Q, Zhang T, Yang N Molecules. 2019; 24(13).
PMID: 31261859 PMC: 6651153. DOI: 10.3390/molecules24132404.
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