Endogenous Beta-carbolines As Clonidine-displacing Substances

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2004 Mar 19

PMID 15028582

Citations 7

Authors

E S J Robinson

N J Anderson

J Crosby

D J Nutt

A L Hudson

Affiliations

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Abstract

Endogenous beta-carbolines, such as harmane, are known to occur in mammalian species including humans. Radioligand binding studies have revealed that certain beta-carbolines display high affinity for both I(1) and I(2) imidazoline-binding sites (IBS). Functional studies have shown that the beta-carboline harmane elicits many characteristics expected of an endogenous ligand IBS. This article discusses the evidence relating to beta-carbolines as endogenous ligands and presents a case for harmane and related compounds as endogenous ligands for IBS.

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