Arterial Aging: a Journey into Subclinical Arterial Disease

Overview

Journal Curr Opin Nephrol Hypertens

Specialties Cardiology & Vascular Diseases
Nephrology

Date 2009 Dec 31

PMID 20040868

Citations 78

Authors

Mingyi Wang

Robert E Monticone

Edward G Lakatta

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Age-associated arterial alterations in cells, matrix, and biomolecules are the foundation for the initiation and progression of cardiovascular diseases in older persons. This review focuses on the latest advances on the intertwining of aging and disease within the arterial wall at the cell and molecular levels.

Recent Findings: Endothelial dysfunction, vascular smooth muscle cell (VSMC) proliferation/invasion/secretion, matrix fragmentation, collagenization and glycation are characteristics of an age-associated arterial phenotype that creates a microenvironment enriched with reactive oxygen species (ROS) for the pathogenesis of arterial disease. This niche creates an age-associated arterial secretory phenotype (AAASP), which is orchestrated by the concerted effects of numerous age-modified angiotensin II signaling molecules. Most of these biomolecular, cell, and matrix modifications that constitute the AAASP can be elicited by experimental hypertension or atherosclerosis at a younger age. The arterial AAASP also shares features of a senescence-associated secretory phenotype (SASP) identified in other mesenchymocytes, that is, fibroblasts.

Summary: A subclinical AAASP evolves during aging. Targeting this subclinical AAASP may reduce the incidence and progression of the quintessential age-associated arterial diseases, that is, hypertension and atherosclerosis.

Citing Articles

Vascular aging and cardiovascular disease: pathophysiology and measurement in the coronary arteries.

Cheng D, Climie R, Shu M, Grieve S, Kozor R, Figtree G Front Cardiovasc Med. 2023; 10:1206156.

PMID: 38089775 PMC: 10715672. DOI: 10.3389/fcvm.2023.1206156.

Early vascular aging as an index of cardiovascular risk in healthy adults: confirmatory factor analysis from the EVasCu study.

Saz-Lara A, Cavero-Redondo I, Pascual-Morena C, Martinez-Garcia I, Rodriguez-Gutierrez E, Luceron-Lucas-Torres M Cardiovasc Diabetol. 2023; 22(1):209.

PMID: 37592251 PMC: 10436435. DOI: 10.1186/s12933-023-01947-9.

Epigenomic and Other Evidence for Cannabis-Induced Aging Contextualized in a Synthetic Epidemiologic Overview of Cannabinoid-Related Teratogenesis and Cannabinoid-Related Carcinogenesis.

Reece A, Hulse G Int J Environ Res Public Health. 2022; 19(24).

PMID: 36554603 PMC: 9778714. DOI: 10.3390/ijerph192416721.

Establishment and evaluation of a risk-prediction model for hypertension in elderly patients with NAFLD from a health management perspective.

Zhang A, Luo X, Pan H, Shen X, Liu B, Li D Sci Rep. 2022; 12(1):15138.

PMID: 36071077 PMC: 9452675. DOI: 10.1038/s41598-022-18718-3.

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis.

Ruotsalainen S, Surakka I, Mars N, Karjalainen J, Kurki M, Kanai M Commun Biol. 2022; 5(1):802.

PMID: 35978133 PMC: 9385630. DOI: 10.1038/s42003-022-03552-0.

References

Spinetti G, Wang M, Monticone R, Zhang J, Zhao D, Lakatta E . Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler Thromb Vasc Biol. 2004; 24(8):1397-402. DOI: 10.1161/01.ATV.0000134529.65173.08. View

Lakatta E, Wang M, Najjar S . Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels. Med Clin North Am. 2009; 93(3):583-604, Table of Contents. PMC: 2943242. DOI: 10.1016/j.mcna.2009.02.008. View

Wang M, Zhang J, Jiang L, Spinetti G, Pintus G, Monticone R . Proinflammatory profile within the grossly normal aged human aortic wall. Hypertension. 2007; 50(1):219-27. DOI: 10.1161/HYPERTENSIONAHA.107.089409. View

Scuteri A, Chen C, Yin F, Spurgeon H, Lakatta E . Functional correlates of central arterial geometric phenotypes. Hypertension. 2001; 38(6):1471-5. DOI: 10.1161/hy1201.099291. View

Donato A, Eskurza I, Silver A, Levy A, Pierce G, Gates P . Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ Res. 2007; 100(11):1659-66. DOI: 10.1161/01.RES.0000269183.13937.e8. View

Collins A, Lyon C, Xia X, Liu J, Tangirala R, Yin F . Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ Res. 2009; 104(6):e42-54. DOI: 10.1161/CIRCRESAHA.108.188771. View

Virmani R, Avolio A, Mergner W, Robinowitz M, Herderick E, Cornhill J . Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities. Am J Pathol. 1991; 139(5):1119-29. PMC: 1886332. View

Basso N, Cini R, Pietrelli A, Ferder L, Terragno N, Inserra F . Protective effect of long-term angiotensin II inhibition. Am J Physiol Heart Circ Physiol. 2007; 293(3):H1351-8. DOI: 10.1152/ajpheart.00393.2007. View

Wang M, Takagi G, Asai K, Resuello R, Natividad F, Vatner D . Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates. Hypertension. 2003; 41(6):1308-16. DOI: 10.1161/01.HYP.0000073843.56046.45. View

10.

Rodier F, Coppe J, Patil C, Hoeijmakers W, Munoz D, Raza S . Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol. 2009; 11(8):973-9. PMC: 2743561. DOI: 10.1038/ncb1909. View

11.

Smith B, Lightfoot S, Lerner M, Denson K, Morgan D, Hanas J . Induction of cardiovascular pathology in a novel model of low-grade chronic inflammation. Cardiovasc Pathol. 2008; 18(1):1-10. DOI: 10.1016/j.carpath.2007.07.011. View

12.

Mahmoudi M, Gorenne I, Mercer J, Figg N, Littlewood T, Bennett M . Statins use a novel Nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. Circ Res. 2008; 103(7):717-25. DOI: 10.1161/CIRCRESAHA.108.182899. View

13.

Lakatta E . Central arterial aging and the epidemic of systolic hypertension and atherosclerosis. J Am Soc Hypertens. 2010; 1(5):302-40. DOI: 10.1016/j.jash.2007.05.001. View

14.

Uddin M, Yang H, Shi M, Polley-Mandal M, Guo Z . Elevation of oxidative stress in the aorta of genetically hypertensive mice. Mech Ageing Dev. 2003; 124(7):811-7. DOI: 10.1016/s0047-6374(03)00135-0. View

15.

Susic D, Varagic J, Ahn J, Frohlich E . Cardiovascular and renal effects of a collagen cross-link breaker (ALT 711) in adult and aged spontaneously hypertensive rats. Am J Hypertens. 2004; 17(4):328-33. DOI: 10.1016/j.amjhyper.2003.12.015. View

16.

Li Z, Cheng H, Lederer W, Froehlich J, Lakatta E . Enhanced proliferation and migration and altered cytoskeletal proteins in early passage smooth muscle cells from young and old rat aortic explants. Exp Mol Pathol. 1997; 64(1):1-11. DOI: 10.1006/exmp.1997.2204. View

17.

Costopoulos C, Liew T, Bennett M . Ageing and atherosclerosis: Mechanisms and therapeutic options. Biochem Pharmacol. 2007; 75(6):1251-61. DOI: 10.1016/j.bcp.2007.10.006. View

18.

Wu R, Millette E, Wu L, de Champlain J . Enhanced superoxide anion formation in vascular tissues from spontaneously hypertensive and desoxycorticosterone acetate-salt hypertensive rats. J Hypertens. 2001; 19(4):741-8. DOI: 10.1097/00004872-200104000-00011. View

19.

Wang M, Lakatta E . The salted artery and angiotensin II signaling: a deadly duo in arterial disease. J Hypertens. 2008; 27(1):19-21. PMC: 3091136. DOI: 10.1097/HJH.0b013e32831d1fed. View

20.

Yang D, McCrann D, Nguyen H, St Hilaire C, DePinho R, Jones M . Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell. 2007; 6(2):257-60. PMC: 3303600. DOI: 10.1111/j.1474-9726.2007.00274.x. View