Isomer Specificity of Conjugated Linoleic Acid (CLA): 9E,11E-CLA

Overview

Journal Nutr Res Pract

Specialty Nutritional Sciences

Date 2009 Dec 18

PMID 20016738

Citations 1

Authors

Yunkyoung Lee

Affiliations

Soon will be listed here.

Abstract

Conjugated linoleic acids (CLA) were identified in 1980's, since then it has been intensively studied due to its various beneficial health effects such as anti-inflammatory, anti-atherogenic, anti-carcinogenic and anti-diabetic/obesity effects. Isomer specificity of a number of CLA isomers, especially predominant isomer 9Z,11E- and 10E,12Z-CLA, is now recognized. However, the less prevalent CLA isomers have not been well characterized. Recently, studies have reported the distinctively different effects of 9E,11E-CLA in colon cancer cells, endothelial cells, and macrophage cells compared to the rest of CLA isomers. In this review, various effects of CLAs, especially anti-inflammatory and anti-atherogenic effects, will be discussed with focusing on the isomer-specific effects and potential mechanism of action of CLA. At last, recent studies about 9E,11E-CLA in in vitro and animal models will be discussed.

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References

Tricon S, Burdge G, Kew S, Banerjee T, Russell J, Jones E . Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans. Am J Clin Nutr. 2004; 80(3):614-20. DOI: 10.1093/ajcn/80.3.614. View

Kelly G . Conjugated linoleic acid: a review. Altern Med Rev. 2001; 6(4):367-82. View

Benito P, NELSON G, Kelley D, Bartolini G, Schmidt P, Simon V . The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans. Lipids. 2001; 36(3):229-36. DOI: 10.1007/s11745-001-0712-x. View

Nestel P, Fujii A, Allen T . The cis-9,trans-11 isomer of conjugated linoleic acid (CLA) lowers plasma triglyceride and raises HDL cholesterol concentrations but does not suppress aortic atherosclerosis in diabetic apoE-deficient mice. Atherosclerosis. 2006; 189(2):282-7. DOI: 10.1016/j.atherosclerosis.2005.12.020. View

Ross R . Atherosclerosis--an inflammatory disease. N Engl J Med. 1999; 340(2):115-26. DOI: 10.1056/NEJM199901143400207. View

Nicolosi R, Rogers E, Kritchevsky D, Scimeca J, Huth P . Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery. 1997; 22(5):266-77. View

Toomey S, Harhen B, Roche H, Fitzgerald D, Belton O . Profound resolution of early atherosclerosis with conjugated linoleic acid. Atherosclerosis. 2005; 187(1):40-9. DOI: 10.1016/j.atherosclerosis.2005.08.024. View

Rahman M, Bhattacharya A, Banu J, Fernandes G . Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female mice. J Nutr Biochem. 2006; 18(7):467-74. DOI: 10.1016/j.jnutbio.2006.08.002. View

Pariza M . Perspective on the safety and effectiveness of conjugated linoleic acid. Am J Clin Nutr. 2004; 79(6 Suppl):1132S-1136S. DOI: 10.1093/ajcn/79.6.1132S. View

10.

Nugent A, Roche H, Noone E, Long A, Kelleher D, Gibney M . The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers. Eur J Clin Nutr. 2005; 59(6):742-50. DOI: 10.1038/sj.ejcn.1602132. View

11.

Ritzenthaler K, McGuire M, McGuire M, Shultz T, Koepp A, Luedecke L . Consumption of conjugated linoleic acid (CLA) from CLA-enriched cheese does not alter milk fat or immunity in lactating women. J Nutr. 2005; 135(3):422-30. DOI: 10.1093/jn/135.3.422. View

12.

Luongo D, Bergamo P, Rossi M . Effects of conjugated linoleic acid on growth and cytokine expression in Jurkat T cells. Immunol Lett. 2003; 90(2-3):195-201. DOI: 10.1016/j.imlet.2003.09.012. View

13.

Cheng W, Lii C, Chen H, Lin T, Liu K . Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappaB pathway. J Agric Food Chem. 2004; 52(1):71-8. DOI: 10.1021/jf0348626. View

14.

Munday J, Thompson K, James K . Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model. Br J Nutr. 1999; 81(3):251-5. DOI: 10.1017/s0007114599000458. View

15.

Arbones-Mainar J, Navarro M, Guzman M, Arnal C, Surra J, Acin S . Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice. Atherosclerosis. 2006; 189(2):318-27. DOI: 10.1016/j.atherosclerosis.2006.01.015. View

16.

Petridou A, Mougios V, Sagredos A . Supplementation with CLA: isomer incorporation into serum lipids and effect on body fat of women. Lipids. 2003; 38(8):805-11. DOI: 10.1007/s11745-003-1129-2. View

17.

Kritchevsky D, Tepper S, Wright S, Tso P, Czarnecki S . Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. J Am Coll Nutr. 2000; 19(4):472S-477S. DOI: 10.1080/07315724.2000.10718950. View

18.

Kramer J, Parodi P, Jensen R, Mossoba M, Yurawecz M, Adlof R . Rumenic acid: a proposed common name for the major conjugated linoleic acid isomer found in natural products. Lipids. 1998; 33(8):835. DOI: 10.1007/s11745-998-0279-6. View

19.

Kelley D, Taylor P, Rudolph I, Benito P, NELSON G, Mackey B . Dietary conjugated linoleic acid did not alter immune status in young healthy women. Lipids. 2000; 35(10):1065-71. DOI: 10.1007/s11745-000-0620-0. View

20.

Whigham L, Cook M, Atkinson R . Conjugated linoleic acid: implications for human health. Pharmacol Res. 2000; 42(6):503-10. DOI: 10.1006/phrs.2000.0735. View