Pain Modulation by Nitric Oxide in the Spinal Cord

Overview

Journal Front Neurosci

Date 2009 Dec 17

PMID 20011139

Citations 43

Authors

Marco Aurelio M Freire

Joanilson S Guimaraes

Walace Gomes Leal

Antonio Pereira

Affiliations

Soon will be listed here.

Abstract

Nitric oxide (NO) is a versatile messenger molecule first associated with endothelial relaxing effects. In the central nervous system (CNS), NO synthesis is primarily triggered by activation of N-methyl-D-aspartate (NMDA) receptors and has a Janus face, with both beneficial and harmful properties. There are three isoforms of the NO synthesizing enzyme nitric oxide synthase (NOS): neuronal (nNOS), endothelial (eNOS), and inducible nitric oxide synthase (iNOS), each one involved with specific events in the brain. In the CNS, nNOS is involved with modulation of synaptic transmission through long-term potentiation in several regions, including nociceptive circuits in the spinal cord. Here, we review the role played by NO on central pain sensitization.

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References

Xiao Y, Diao Y, So K . A morphological study of neurons expressing NADPH diaphorase activity in the visual cortex of the golden hamster. Brain Behav Evol. 1996; 48(4):221-30. DOI: 10.1159/000113200. View

Yan X, Jen L, Garey L . NADPH-diaphorase-positive neurons in primate cerebral cortex colocalize with GABA and calcium-binding proteins. Cereb Cortex. 1996; 6(3):524-9. DOI: 10.1093/cercor/6.3.524. View

Tao Y, Hassan A, Haddad E, Johns R . Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord. Neuroscience. 2000; 95(2):525-33. DOI: 10.1016/s0306-4522(99)00438-8. View

Marletta M . Nitric oxide synthase: aspects concerning structure and catalysis. Cell. 1994; 78(6):927-30. DOI: 10.1016/0092-8674(94)90268-2. View

Haghikia A, Mergia E, Friebe A, Eysel U, Koesling D, Mittmann T . Long-term potentiation in the visual cortex requires both nitric oxide receptor guanylyl cyclases. J Neurosci. 2007; 27(4):818-23. PMC: 6672906. DOI: 10.1523/JNEUROSCI.4706-06.2007. View

Wall P, Kerr B, Ramer M . Primary afferent input to and receptive field properties of cells in rat lumbar area X. J Comp Neurol. 2002; 449(3):298-306. DOI: 10.1002/cne.10294. View

PEREIRA Jr A, Freire M, Bahia C, Franca J, Picanco-Diniz C . The barrel field of the adult mouse SmI cortex as revealed by NADPH-diaphorase histochemistry. Neuroreport. 2000; 11(9):1889-92. DOI: 10.1097/00001756-200006260-00017. View

Hope B, Michael G, Knigge K, Vincent S . Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci U S A. 1991; 88(7):2811-4. PMC: 51329. DOI: 10.1073/pnas.88.7.2811. View

Toda N, Ayajiki K, Okamura T . Nitric oxide and penile erectile function. Pharmacol Ther. 2005; 106(2):233-66. DOI: 10.1016/j.pharmthera.2004.11.011. View

10.

Hassiotis M, Paxinos G, Ashwell K . Cyto- and chemoarchitecture of the cerebral cortex of an echidna (Tachyglossus aculeatus). II. Laminar organization and synaptic density. J Comp Neurol. 2004; 482(1):94-122. DOI: 10.1002/cne.20353. View

11.

Lipton S, Rosenberg P . Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994; 330(9):613-22. DOI: 10.1056/NEJM199403033300907. View

12.

Bredt D, Glatt C, Hwang P, Fotuhi M, Dawson T, Snyder S . Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron. 1991; 7(4):615-24. DOI: 10.1016/0896-6273(91)90374-9. View

13.

Guix F, Uribesalgo I, Coma M, Munoz F . The physiology and pathophysiology of nitric oxide in the brain. Prog Neurobiol. 2005; 76(2):126-52. DOI: 10.1016/j.pneurobio.2005.06.001. View

14.

Wiencken A, Casagrande V . The distribution of NADPH diaphorase and nitric oxide synthetase (NOS) in relation to the functional compartments of areas V1 and V2 of primate visual cortex. Cereb Cortex. 2000; 10(5):499-511. DOI: 10.1093/cercor/10.5.499. View

15.

Esplugues J . NO as a signalling molecule in the nervous system. Br J Pharmacol. 2002; 135(5):1079-95. PMC: 1573233. DOI: 10.1038/sj.bjp.0704569. View

16.

Brenman J, Bredt D . Nitric oxide signaling in the nervous system. Methods Enzymol. 1996; 269:119-29. DOI: 10.1016/s0076-6879(96)69014-4. View

17.

Mendell L, WALL P . PRESYNAPTIC HYPERPOLARIZATION: A ROLE FOR FINE AFFERENT FIBRES. J Physiol. 1964; 172:274-94. PMC: 1368832. DOI: 10.1113/jphysiol.1964.sp007417. View

18.

Todd A, Puskar Z, Spike R, Hughes C, Watt C, Forrest L . Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance p-containing afferents and respond to noxious stimulation. J Neurosci. 2002; 22(10):4103-13. PMC: 6757649. DOI: 20026261. View

19.

Wu J, Su G, Ma L, Zhang X, Lei Y, Li J . Protein kinases mediate increment of the phosphorylation of cyclic AMP-responsive element binding protein in spinal cord of rats following capsaicin injection. Mol Pain. 2005; 1:26. PMC: 1224868. DOI: 10.1186/1744-8069-1-26. View

20.

Guimaraes J, Freire M, Lima R, Souza-Rodrigues R, Costa A, Dos Santos C . [Mechanisms of secondary degeneration in the central nervous system during acute neural disorders and white matter damage]. Rev Neurol. 2009; 48(6):304-10. View