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Magnesium Sulfate Reduces Carrageenan-Induced Rat Paw Inflammatory Edema Via Nitric Oxide Production

Overview
Journal Dose Response
Publisher Sage Publications
Date 2023 Feb 9
PMID 36756149
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Abstract

Background: Magnesium is an antagonist of the N-methyl-D-aspartate receptor. This study aimed to investigate the anti-edematous effect of magnesium sulfate (MS) in different protocols of use and the possible mechanism of its action.

Methods: In a rat model of carrageenan-induced paw inflammation, the anti-edematous activity of MS was assessed with a plethysmometer. The effects of the nonselective inhibitor (L-NAME), selective inhibitor of neuronal (L-NPA) and inducible (SMT) nitric oxide synthase on the effects of MS were evaluated.

Results: MS administered systemically before or after inflammation reduced edema by 30% (5 mg/kg, < .05) and 55% (30 mg/kg, < .05). MS administered locally (.5 mg/paw, < .05) significantly prevented the development of inflammatory edema by 60%. L-NAME, intraperitoneally administered before MS, potentiated (5 mg/kg, < .05) or reduced (3 mg/kg, < .05), while in the highest tested dose L-NPA (2 mg/kg, < .01) and SMT (.015 mg/kg, < .01) reduced the anti-edematous effect of MS.

Conclusions: Magnesium is a more effective anti-edematous drug in therapy than for preventing inflammatory edema. The effect of MS is achieved after systemic and local peripheral administration and when MS is administered as a single drug in a single dose. This effect is mediated at least in part via the production of nitric oxide.

Citing Articles

The Interactions of Magnesium Sulfate and Cromoglycate in a Rat Model of Orofacial Pain; The Role of Magnesium on Mast Cell Degranulation in Neuroinflammation.

Srebro D, Dozic B, Vuckovic S, Savic Vujovic K, Medic Brkic B, Dozic I Int J Mol Sci. 2023; 24(7).

PMID: 37047214 PMC: 10094402. DOI: 10.3390/ijms24076241.

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