Destructive Arthritis in a Patient with Chikungunya Virus Infection with Persistent Specific IgM Antibodies

Overview

Journal BMC Infect Dis

Publisher Biomed Central

Specialty Infectious Diseases

Date 2009 Dec 17

PMID 20003320

Citations 47

Authors

Denis Malvy

Khaled Ezzedine

Maria Mamani-Matsuda

Brigitte Autran

Hugues Tolou

Marie-Catherine Receveur

Thierry Pistone

Jerome Rambert

Daniel Moynet

Djavad Mossalayi

Affiliations

Soon will be listed here.

Abstract

Background: Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood.

Case Presentation: We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection.

Conclusions: Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.

Citing Articles

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Bone erosions and joint damage caused by chikungunya virus: a systematic review.

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Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection.

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References

Cohen A, Shoenfeld Y . The viral-autoimmunity relationship. Viral Immunol. 1995; 8(1):1-9. DOI: 10.1089/vim.1995.8.1. View

Lidbury B, Rulli N, Suhrbier A, Smith P, McColl S, Cunningham A . Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus. J Infect Dis. 2008; 197(11):1585-93. DOI: 10.1086/587841. View

Fourie E, Morrison J . Rheumatoid arthritic syndrome after chikungunya fever. S Afr Med J. 1979; 56(4):130-2. View

Ozden S, Huerre M, Riviere J, Coffey L, Afonso P, Mouly V . Human muscle satellite cells as targets of Chikungunya virus infection. PLoS One. 2007; 2(6):e527. PMC: 1885285. DOI: 10.1371/journal.pone.0000527. View

Dinarello C . Biologic basis for interleukin-1 in disease. Blood. 1996; 87(6):2095-147. View

Borgherini G, Poubeau P, Jossaume A, Gouix A, Cotte L, Michault A . Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on reunion island. Clin Infect Dis. 2008; 47(4):469-75. DOI: 10.1086/590003. View

Khan M, Mathieu A, Sorrentino R, Akkoc N . The pathogenetic role of HLA-B27 and its subtypes. Autoimmun Rev. 2007; 6(3):183-9. DOI: 10.1016/j.autrev.2006.11.003. View

Qiao X, He B, Chiu A, Knowles D, Chadburn A, Cerutti A . Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells. Nat Immunol. 2006; 7(3):302-10. DOI: 10.1038/ni1302. View

Pastorino B, Bessaud M, Grandadam M, Murri S, Tolou H, Peyrefitte C . Development of a TaqMan RT-PCR assay without RNA extraction step for the detection and quantification of African Chikungunya viruses. J Virol Methods. 2005; 124(1-2):65-71. DOI: 10.1016/j.jviromet.2004.11.002. View

10.

Honda K, Takaoka A, Taniguchi T . Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity. 2006; 25(3):349-60. DOI: 10.1016/j.immuni.2006.08.009. View

11.

Sourisseau M, Schilte C, Casartelli N, Trouillet C, Guivel-Benhassine F, Rudnicka D . Characterization of reemerging chikungunya virus. PLoS Pathog. 2007; 3(6):e89. PMC: 1904475. DOI: 10.1371/journal.ppat.0030089. View

12.

Takeuchi O, Akira S . Recognition of viruses by innate immunity. Immunol Rev. 2007; 220:214-24. DOI: 10.1111/j.1600-065X.2007.00562.x. View

13.

Suhrbier A, Linn M . Clinical and pathologic aspects of arthritis due to Ross River virus and other alphaviruses. Curr Opin Rheumatol. 2004; 16(4):374-9. DOI: 10.1097/01.bor.0000130537.76808.26. View

14.

Grivard P, Le Roux K, Laurent P, Fianu A, Perrau J, Gigan J . Molecular and serological diagnosis of Chikungunya virus infection. Pathol Biol (Paris). 2007; 55(10):490-4. DOI: 10.1016/j.patbio.2007.07.002. View

15.

Sissoko D, Malvy D, Ezzedine K, Renault P, Moscetti F, Ledrans M . Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period. PLoS Negl Trop Dis. 2009; 3(3):e389. PMC: 2647734. DOI: 10.1371/journal.pntd.0000389. View

16.

Couderc T, Chretien F, Schilte C, Disson O, Brigitte M, Guivel-Benhassine F . A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog. 2008; 4(2):e29. PMC: 2242832. DOI: 10.1371/journal.ppat.0040029. View

17.

Sissoko D, Moendandze A, Malvy D, Giry C, Ezzedine K, Solet J . Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey. PLoS One. 2008; 3(8):e3066. PMC: 2518850. DOI: 10.1371/journal.pone.0003066. View

18.

Enserink M . Infectious diseases. Massive outbreak draws fresh attention to little-known virus. Science. 2006; 311(5764):1085. DOI: 10.1126/science.311.5764.1085a. View

19.

Rot A, von Andrian U . Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol. 2004; 22:891-928. DOI: 10.1146/annurev.immunol.22.012703.104543. View

20.

Shoenfeld Y . Common infections, idiotypic dysregulation, autoantibody spread and induction of autoimmune diseases. J Autoimmun. 1996; 9(2):235-9. DOI: 10.1006/jaut.1996.0029. View