Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Sep 9

PMID 37685893

Authors

Amanda M Avila-Trejo

Lorena I Rodriguez-Paez

Veronica Alcantara-Farfan

J Leopoldo Aguilar-Faisal

Affiliations

Soon will be listed here.

Abstract

Chronic cases of chikungunya fever represent a public health problem in countries where the virus circulates. The disease is prolonged, in some cases, for years, resulting in disabling pain and bone erosion among other bone and joint problems. As time progresses, tissue damage is persistent, although the virus has not been found in blood or joints. The pathogenesis of these conditions has not been fully explained. Additionally, it has been considered that there are multiple factors that might intervene in the viral pathogenesis of the different conditions that develop. Other mechanisms involved in osteoarthritic diseases of non-viral origin could help explain how damage is produced in chronic conditions. The aim of this review is to analyze the molecular and cellular factors that could be involved in the tissue damage generated by different infectious conditions of the chikungunya virus.

Citing Articles

Acute Immunological Profile and Prognostic Biomarkers of Persistent Joint Pain in Chikungunya Fever: A Systematic Review.

Lozano-Parra A, Herrera V, Urcuqui-Inchima S, Ramirez R, Villar L Yale J Biol Med. 2024; 97(4):473-489.

PMID: 39703607 PMC: 11650912. DOI: 10.59249/RQYJ3197.

Chronic Rheumatologic Disease in Chikungunya Virus Fever: Results from a Cohort Study Conducted in Piedecuesta, Colombia.

Lozano-Parra A, Herrera V, Calderon C, Badillo R, Ramirez R, Estupinan Cardenas M Trop Med Infect Dis. 2024; 9(10).

PMID: 39453274 PMC: 11511048. DOI: 10.3390/tropicalmed9100247.

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