Liprin (beta)1 is Highly Expressed in Lymphatic Vasculature and is Important for Lymphatic Vessel Integrity

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2009 Dec 8

PMID 19965622

Citations 28

Authors

Camilla Norrmen

Wouter Vandevelde

Annelii Ny

Pipsa Saharinen

Massimiliano Gentile

Guttorm Haraldsen

Pauli Puolakkainen

Eugene Lukanidin

Mieke Dewerchin

Kari Alitalo

Tatiana V Petrova

Affiliations

Soon will be listed here.

Abstract

The lymphatic vasculature is important for the regulation of tissue fluid homeostasis, immune response, and lipid absorption, and the development of in vitro models should allow for a better understanding of the mechanisms regulating lymphatic vascular growth, repair, and function. Here we report isolation and characterization of lymphatic endothelial cells from human intestine and show that intestinal lymphatic endothelial cells have a related but distinct gene expression profile from human dermal lymphatic endothelial cells. Furthermore, we identify liprin beta1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, as highly expressed in intestinal lymphatic endothelial cells in vitro and lymphatic vasculature in vivo, and show that it plays an important role in the maintenance of lymphatic vessel integrity in Xenopus tadpoles.

Citing Articles

Molecular and metabolic orchestration of the lymphatic vasculature in physiology and pathology.

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The emerging roles of long noncoding RNAs in lymphatic vascular development and disease.

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Blood endothelial ALK1-BMP4 signaling axis regulates adult hair follicle stem cell activation.

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Liprins in oncogenic signaling and cancer cell adhesion.

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