A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-associated Glycoprotein 2

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2009 Dec 8

PMID 19962670

Citations 150

Authors

Samuel C Mok

Tomas Bonome

Vinod Vathipadiekal

Aaron Bell

Michael E Johnson

Kwong-Kwok Wong

Dong-Choon Park

Ke Hao

Daniel K P Yip

Howard Donninger

Laurent Ozbun

Goli Samimi

John Brady

Mike Randonovich

Cindy A Pise-Masison

J Carl Barrett

Wing H Wong

William R Welch

Ross S Berkowitz

Michael J Birrer

Affiliations

Soon will be listed here.

Abstract

Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the alpha(V)beta(3) integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.

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