Multiple Gastrointestinal Stromal Tumors in Neurofibromatosis Type 1: Report of a Case

Overview

Journal Surg Today

Specialty General Surgery

Date 2009 Nov 3

PMID 19882321

Citations 8

Authors

Kotaro Hirashima

Hiroshi Takamori

Masahiko Hirota

Hiroshi Tanaka

Atsushi Ichihara

Yasuo Sakamoto

Yoshiaki Ikuta

Ryu-ichi Karashima

Masayuki Watanabe

Ken-Ichi Iyama

Hideo Baba

Affiliations

Soon will be listed here.

Abstract

This report presents a case of multiple gastrointestinal stromal tumors (GIST) with neurofibromatosis type 1 (NF1). A 68-year-old woman was admitted to the hospital because of a tumor close to the head of the pancreas. Imaging studies revealed submucosal tumors of the duodenum. The retroperitoneal tumor was diagnosed before surgery. Besides the main tumor in the duodenum, multiple small submucosal tumors were found in the duodenum and upper part of the jejunum during the operation. All of these tumors were resected. The histological diagnosis of all these tumors was GISTs. These tumors were immunohistochemically positive for KIT, but they demonstrated no mutation in c-kit exons 9, 11, 13, and 17, and platelet-derived growth factor receptor alpha exons 12 and 18. No recurrence occurred for a year after surgery.

Citing Articles

Surgical treatment of gastrointestinal stromal tumors of the duodenum: a literature review.

Popivanov G, Tabakov M, Mantese G, Cirocchi R, Piccinini I, DAndrea V Transl Gastroenterol Hepatol. 2018; 3:71.

PMID: 30363779 PMC: 6182027. DOI: 10.21037/tgh.2018.09.04.

Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum.

Tokunaga M, Nanjo S, Yoshita H, Fujinami H, Watanabe T, Ishii Y Intern Med. 2018; 57(12):1719-1723.

PMID: 29434135 PMC: 6047988. DOI: 10.2169/internalmedicine.0229-17.

A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1.

Yamamoto Y, Kodama K, Yokoyama S, Takeda M, Michishita S Case Rep Surg. 2015; 2015:375416.

PMID: 26442164 PMC: 4579307. DOI: 10.1155/2015/375416.

Gastrointestinal stromal tumors associated with neurofibromatosis 1: a single centre experience and systematic review of the literature including 252 cases.

Salvi P, Lorenzon L, Caterino S, Antolino L, Antonelli M, Balducci G Int J Surg Oncol. 2014; 2013:398570.

PMID: 24386562 PMC: 3872280. DOI: 10.1155/2013/398570.

An Unusual Presentation of GIST.

Chan V, Hariharan V, Tweedie J, Phillips B J Gastrointest Cancer. 2012; 43 Suppl 1:S273-5.

PMID: 22810505 DOI: 10.1007/s12029-012-9415-0.

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