Laparoscopic Total Gastrectomy for Multiple Sporadic Gastric Gastrointestinal Stromal Tumors: Report of a Case

Overview

Journal Surg Today

Specialty General Surgery

Date 2011 Nov 3

PMID 22045229

Citations 2

Authors

Akihisa Fujimoto

Toshihiro Kobayashi

Shigeki Uchida

You Ichinose

Tetsu Sasaoki

Kenzo Goto

Hiroshi Okabe

Affiliations

Soon will be listed here.

Abstract

A 64-year-old man was admitted to our hospital with hematemesis. Emergency upper gastrointestinal endoscopy revealed bleeding from a submucosal tumor (SMT) in the antrum of the stomach, with two other SMTs at different sites. Based on his family history, we diagnosed familial multiple gastric gastrointestinal stromal tumors (GISTs) and performed laparoscopic total gastrectomy. Three distinct tumors were found: one in the fornix, one in the lesser curvature of the angle, and one in the antrum of the stomach. Microscopic examination of the resected specimens revealed different cytomorphologies, of the spindle and epithelioid type, as well as immunophenotypes in the tumors. Mutation analysis revealed different sites of mutation in c-kit and PDGFRA. No mutation was detected in the normal tissue of the stomach. These findings confirmed a diagnosis of multiple sporadic gastric GISTs. Thus, investigating germline mutation might assist in the preoperative diagnosis of multiple gastric GISTs.

Citing Articles

Surgical resection should be taken into consideration for the treatment of small gastric gastrointestinal stromal tumors.

Yang J, Feng F, Li M, Sun L, Hong L, Cai L World J Surg Oncol. 2013; 11:273.

PMID: 24119564 PMC: 3852122. DOI: 10.1186/1477-7819-11-273.

Synchronous sporadic gastrointestinal stromal tumors in the stomach and jejunum: report of a case.

Nakayama Y, Kadowaki K, Higure A, Hisaoka M, Yamaguchi K Case Rep Gastroenterol. 2013; 7(1):69-74.

PMID: 23626506 PMC: 3617895. DOI: 10.1159/000348754.

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