Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum

Overview

Journal Intern Med

Specialty General Medicine

Date 2018 Feb 14

PMID 29434135

Citations 2

Authors

Mami Tokunaga

Sohachi Nanjo

Hiroki Yoshita

Haruka Fujinami

Tohru Watanabe

Yoko Ishii

Saito Kobayashi

Momoko Akashi

Hiroaki Takagi

Hiroshi Mihara

Shinya Kajiura

Takayuki Ando

Isaya Hashimoto

Shozo Hojo

Tomoyuki Okumura

Toshiro Sugiyama

Affiliations

Soon will be listed here.

Abstract

A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins. This report depicts an extremely rare case of multiple synchronous sporadic GISTs in the stomach and jejunum.

Citing Articles

Targeted Deep Sequencing Reveals Unrecognized KIT Mutation Coexistent with NF1 Deficiency in GISTs.

Wu J, Zhou H, Yi X, He Q, Lei T, Tan F Cancer Manag Res. 2021; 13:297-306.

PMID: 33469372 PMC: 7811451. DOI: 10.2147/CMAR.S280174.

Multiple heterochronic gastrointestinal stromal tumors in the stomach detected 6 years after resection: a case report.

Yasuda T, Eto K, Yoshida N, Iwagami S, Hiyoshi Y, Nagai Y Surg Case Rep. 2020; 6(1):48.

PMID: 32146688 PMC: 7060937. DOI: 10.1186/s40792-020-00812-1.

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