Common Sense About Taste: from Mammals to Insects

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2009 Oct 20

PMID 19837029

Citations 338

Authors

David A Yarmolinsky

Charles S Zuker

Nicholas J P Ryba

Affiliations

Soon will be listed here.

Abstract

The sense of taste is a specialized chemosensory system dedicated to the evaluation of food and drink. Despite the fact that vertebrates and insects have independently evolved distinct anatomic and molecular pathways for taste sensation, there are clear parallels in the organization and coding logic between the two systems. There is now persuasive evidence that tastant quality is mediated by labeled lines, whereby distinct and strictly segregated populations of taste receptor cells encode each of the taste qualities.

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References

Mueller K, Hoon M, Erlenbach I, Chandrashekar J, Zuker C, Ryba N . The receptors and coding logic for bitter taste. Nature. 2005; 434(7030):225-9. DOI: 10.1038/nature03352. View

Kataoka S, Yang R, Ishimaru Y, Matsunami H, Sevigny J, Kinnamon J . The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse. Chem Senses. 2007; 33(3):243-54. PMC: 2642677. DOI: 10.1093/chemse/bjm083. View

Kinnamon J, Henzler D, Royer S . HVEM ultrastructural analysis of mouse fungiform taste buds, cell types, and associated synapses. Microsc Res Tech. 1993; 26(2):142-56. DOI: 10.1002/jemt.1070260207. View

Huang A, Chen X, Hoon M, Chandrashekar J, Guo W, Trankner D . The cells and logic for mammalian sour taste detection. Nature. 2006; 442(7105):934-8. PMC: 1571047. DOI: 10.1038/nature05084. View

Clapp T, Yang R, Stoick C, Kinnamon S, Kinnamon J . Morphologic characterization of rat taste receptor cells that express components of the phospholipase C signaling pathway. J Comp Neurol. 2003; 468(3):311-21. DOI: 10.1002/cne.10963. View

Inoshita T, Tanimura T . Cellular identification of water gustatory receptor neurons and their central projection pattern in Drosophila. Proc Natl Acad Sci U S A. 2006; 103(4):1094-9. PMC: 1347963. DOI: 10.1073/pnas.0502376103. View

Lee Y, Moon S, Montell C . Multiple gustatory receptors required for the caffeine response in Drosophila. Proc Natl Acad Sci U S A. 2009; 106(11):4495-500. PMC: 2657413. DOI: 10.1073/pnas.0811744106. View

Cui M, Jiang P, Maillet E, Max M, Margolskee R, Osman R . The heterodimeric sweet taste receptor has multiple potential ligand binding sites. Curr Pharm Des. 2006; 12(35):4591-600. DOI: 10.2174/138161206779010350. View

Kim U, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D . Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science. 2003; 299(5610):1221-5. DOI: 10.1126/science.1080190. View

10.

Chyb S, Dahanukar A, Wickens A, Carlson J . Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proc Natl Acad Sci U S A. 2003; 100 Suppl 2:14526-30. PMC: 304113. DOI: 10.1073/pnas.2135339100. View

11.

Murray R, Murray A, Fujimoto S . Fine structure of gustatory cells in rabbit taste buds. J Ultrastruct Res. 1969; 27(5):444-61. DOI: 10.1016/s0022-5320(69)80043-2. View

12.

Zhao G, Zhang Y, Hoon M, Chandrashekar J, Erlenbach I, Ryba N . The receptors for mammalian sweet and umami taste. Cell. 2003; 115(3):255-66. DOI: 10.1016/s0092-8674(03)00844-4. View

13.

Huang Y, Maruyama Y, Dvoryanchikov G, Pereira E, Chaudhari N, Roper S . The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci U S A. 2007; 104(15):6436-41. PMC: 1851090. DOI: 10.1073/pnas.0611280104. View

14.

Nelson G, Hoon M, Chandrashekar J, Zhang Y, Ryba N, Zuker C . Mammalian sweet taste receptors. Cell. 2001; 106(3):381-90. DOI: 10.1016/s0092-8674(01)00451-2. View

15.

Breslin P, Kaplan J, Spector A, Zambito C, Grill H . Lick rate analysis of sodium taste-state combinations. Am J Physiol. 1993; 264(2 Pt 2):R312-8. DOI: 10.1152/ajpregu.1993.264.2.R312. View

16.

Yasuoka A, Abe K . Gustation in fish: search for prototype of taste perception. Results Probl Cell Differ. 2009; 47:239-55. DOI: 10.1007/400_2008_6. View

17.

Stevens D, Seifert R, Bufe B, Muller F, Kremmer E, Gauss R . Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Nature. 2001; 413(6856):631-5. DOI: 10.1038/35098087. View

18.

Roper S . Parallel processing in mammalian taste buds?. Physiol Behav. 2009; 97(5):604-8. PMC: 3717265. DOI: 10.1016/j.physbeh.2009.04.003. View

19.

Gordon M, Scott K . Motor control in a Drosophila taste circuit. Neuron. 2009; 61(3):373-84. PMC: 2650400. DOI: 10.1016/j.neuron.2008.12.033. View

20.

Jiao Y, Moon S, Wang X, Ren Q, Montell C . Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr Biol. 2008; 18(22):1797-801. PMC: 2676565. DOI: 10.1016/j.cub.2008.10.009. View