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» Articles » PMID: 19808921

Ingestion of Diet Soda Before a Glucose Load Augments Glucagon-like Peptide-1 Secretion

Overview
Journal Diabetes Care
Specialty Endocrinology
Date 2009 Oct 8
PMID 19808921
Citations 78
Authors
Rebecca J Brown
Mary Walter
Kristina I Rother
Affiliations
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Abstract

Objective: The goal of this study was to determine the effect of artificial sweeteners on glucose, insulin, and glucagon-like peptide (GLP)-1 in humans.

Research Design And Methods: For this study, 22 healthy volunteers (mean age 18.5 +/- 4.2 years) underwent two 75-g oral glucose tolerance tests with frequent measurements of glucose, insulin, and GLP-1 for 180 min. Subjects drank 240 ml of diet soda or carbonated water, in randomized order, 10 min prior to the glucose load.

Results: Glucose excursions were similar after ingestion of carbonated water and diet soda. Serum insulin levels tended to be higher after diet soda, without statistical significance. GLP-1 peak and area under the curve (AUC) were significantly higher with diet soda (AUC 24.0 +/- 15.2 pmol/l per 180 min) versus carbonated water (AUC 16.2 +/- 9.0 pmol/l per 180 min; P = 0.003).

Conclusions: Artificial sweeteners synergize with glucose to enhance GLP-1 release in humans. This increase in GLP-1 secretion may be mediated via stimulation of sweet-taste receptors on L-cells by artificial sweetener.

Citing Articles

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Reyes-Lopez Z, Olvera-Hernandez V, Ramos-Garcia M, Mendez J, Guzman-Priego C, Martinez-Lopez M Methods Protoc. 2024; 7(5).

PMID: 39452794 PMC: 11510020. DOI: 10.3390/mps7050080.

Unveiling the profound influence of sucralose on metabolism and its role in shaping obesity trends.

S A, Singh S, Begum R, Vijayan S, Vellapandian C Front Nutr. 2024; 11:1387646.

PMID: 39015535 PMC: 11250074. DOI: 10.3389/fnut.2024.1387646.

Activation and inhibition of the sweet taste receptor TAS1R2-TAS1R3 differentially affect glucose tolerance in humans.

Kochem M, Hanselman E, Breslin P PLoS One. 2024; 19(5):e0298239.

PMID: 38691547 PMC: 11062524. DOI: 10.1371/journal.pone.0298239.

Metabolic Effects of Selected Conventional and Alternative Sweeteners: A Narrative Review.

Teysseire F, Bordier V, Beglinger C, Wolnerhanssen B, Meyer-Gerspach A Nutrients. 2024; 16(5).

PMID: 38474749 PMC: 10933973. DOI: 10.3390/nu16050622.

The Impact of Artificial Sweeteners on Human Health and Cancer Association: A Comprehensive Clinical Review.

Ghusn W, Naik R, Yibirin M Cureus. 2024; 15(12):e51299.

PMID: 38288206 PMC: 10822749. DOI: 10.7759/cureus.51299.

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