T1R2 Receptor-mediated Glucose Sensing in the Upper Intestine Potentiates Glucose Absorption Through Activation of Local Regulatory Pathways

Overview

Journal Mol Metab

Specialty Cell Biology

Date 2018 Sep 12

PMID 30201274

Citations 22

Authors

Kathleen Smith

Elnaz Karimian Azari

Traci E LaMoia

Tania Hussain

Veronika Vargova

Katalin Karolyi

Paula P Veldhuis

Juan Pablo Arnoletti

Sebastian G de la Fuente

Richard E Pratley

Timothy F Osborne

George A Kyriazis

Affiliations

Soon will be listed here.

Abstract

Objective: Beyond the taste buds, sweet taste receptors (STRs; T1R2/T1R3) are also expressed on enteroendocrine cells, where they regulate gut peptide secretion but their regulatory function within the intestine is largely unknown.

Methods: Using T1R2-knock out (KO) mice we evaluated the role of STRs in the regulation of glucose absorption in vivo and in intact intestinal preparations ex vivo.

Results: STR signaling enhances the rate of intestinal glucose absorption specifically in response to the ingestion of a glucose-rich meal. These effects were mediated specifically by the regulation of GLUT2 transporter trafficking to the apical membrane of enterocytes. GLUT2 translocation and glucose transport was dependent and specific to glucagon-like peptide 2 (GLP-2) secretion and subsequent intestinal neuronal activation. Finally, high-sucrose feeding in wild-type mice induced rapid downregulation of STRs in the gut, leading to reduced glucose absorption.

Conclusions: Our studies demonstrate that STRs have evolved to modulate glucose absorption via the regulation of its transport and to prevent the development of exacerbated hyperglycemia due to the ingestion of high levels of sugars.

Citing Articles

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Sun S, Wang A, Kou R, Xue H, Zhao X, Yang B J Diabetes Res. 2024; 2024:5544296.

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