Adenovirus Virion Stability and the Viral Genome: Size Matters

Overview

Journal Mol Ther

Publisher Cell Press

Specialties Molecular Biology
Pharmacology

Date 2009 Oct 1

PMID 19789561

Citations 20

Authors

Michael A Kennedy

Robin J Parks

Affiliations

Soon will be listed here.

Citing Articles

Oncolytic Viruses and Immunotherapy for the Treatment of Uveal Melanoma and Retinoblastoma: The Current Landscape and Novel Advances.

Kulbay M, Tuli N, Mazza M, Jaffer A, Juntipwong S, Marcotte E Biomedicines. 2025; 13(1).

PMID: 39857692 PMC: 11762644. DOI: 10.3390/biomedicines13010108.

Sustained heterologous gene expression in pancreatic islet organoids using adeno-associated virus serotype 8.

Voznesenskaya A, Berggren P, Ilegems E Front Bioeng Biotechnol. 2023; 11:1147244.

PMID: 37545890 PMC: 10400289. DOI: 10.3389/fbioe.2023.1147244.

Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection.

Jennings M, Parks R Viruses. 2023; 15(1).

PMID: 36680201 PMC: 9863843. DOI: 10.3390/v15010161.

Silver Nanoparticles as Potential Antiviral Agents.

Ratan Z, Mashrur F, Chhoan A, Shahriar S, Haidere M, Runa N Pharmaceutics. 2021; 13(12).

PMID: 34959320 PMC: 8705988. DOI: 10.3390/pharmaceutics13122034.

Susceptibility of Dog, Hamster, and Mouse Cells to the Replication-Competent Adenovirus 11p E1/E3 Green Fluorescence Protein Vector Has Implications for the Selection of Animal Vaccine Models.

Gokumakulapalle M, Wang L, Mei Y Front Microbiol. 2021; 12:698999.

PMID: 34777270 PMC: 8578929. DOI: 10.3389/fmicb.2021.698999.

References

Parks R . Adenovirus protein IX: a new look at an old protein. Mol Ther. 2004; 11(1):19-25. DOI: 10.1016/j.ymthe.2004.09.018. View

Mirza M, Weber J . Structure of adenovirus chromatin. Biochim Biophys Acta. 1982; 696(1):76-86. DOI: 10.1016/0167-4781(82)90012-4. View

Lieber A, He C, Kirillova I, Kay M . Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol. 1996; 70(12):8944-60. PMC: 190992. DOI: 10.1128/JVI.70.12.8944-8960.1996. View

Nurmemmedov E, Castelnovo M, Catalano C, Evilevitch A . Biophysics of viral infectivity: matching genome length with capsid size. Q Rev Biophys. 2008; 40(4):327-56. DOI: 10.1017/S0033583508004666. View

Tzlil S, Kindt J, Gelbart W, Ben-Shaul A . Forces and pressures in DNA packaging and release from viral capsids. Biophys J. 2003; 84(3):1616-27. PMC: 1302732. DOI: 10.1016/S0006-3495(03)74971-6. View

Russell W . Adenoviruses: update on structure and function. J Gen Virol. 2008; 90(Pt 1):1-20. DOI: 10.1099/vir.0.003087-0. View

Parks R, Chen L, Anton M, Sankar U, Rudnicki M, Graham F . A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A. 1996; 93(24):13565-70. PMC: 19345. DOI: 10.1073/pnas.93.24.13565. View

Da Poian A, Johnson J, Silva J . Protein-RNA interactions and virus stability as probed by the dynamics of tryptophan side chains. J Biol Chem. 2002; 277(49):47596-602. DOI: 10.1074/jbc.M209174200. View

Nam H, Lane M, Padron E, Gurda B, McKenna R, Kohlbrenner E . Structure of adeno-associated virus serotype 8, a gene therapy vector. J Virol. 2007; 81(22):12260-71. PMC: 2168965. DOI: 10.1128/JVI.01304-07. View

10.

Mizuguchi H, Funakoshi N, Hosono T, Sakurai F, Kawabata K, Yamaguchi T . Rapid construction of small interfering RNA-expressing adenoviral vectors on the basis of direct cloning of short hairpin RNA-coding DNAs. Hum Gene Ther. 2006; 18(1):74-80. DOI: 10.1089/hum.2006.129. View

11.

Everitt E, Lutter L, Philipson L . Structural proteins of adenoviruses. XII. Location and neighbor relationship among proteins of adenovirion type 2 as revealed by enzymatic iodination, immunoprecipitation and chemical cross-linking. Virology. 1975; 67(1):197-208. DOI: 10.1016/0042-6822(75)90417-1. View

12.

Fejer G, Drechsel L, Liese J, Schleicher U, Ruzsics Z, Imelli N . Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo. PLoS Pathog. 2008; 4(11):e1000208. PMC: 2576454. DOI: 10.1371/journal.ppat.1000208. View

13.

Maizel Jr J, WHITE D, Scharff M . The polypeptides of adenovirus. II. Soluble proteins, cores, top components and the structure of the virion. Virology. 1968; 36(1):126-36. DOI: 10.1016/0042-6822(68)90122-0. View

14.

Smith A, Poulin K, Parks R . DNA genome size affects the stability of the adenovirus virion. J Virol. 2008; 83(4):2025-8. PMC: 2643769. DOI: 10.1128/JVI.01644-08. View

15.

Chatterjee P, Vayda M, Flint S . Identification of proteins and protein domains that contact DNA within adenovirus nucleoprotein cores by ultraviolet light crosslinking of oligonucleotides 32P-labelled in vivo. J Mol Biol. 1986; 188(1):23-37. DOI: 10.1016/0022-2836(86)90477-8. View

16.

Newcomb W, Boring J, Brown J . Ion etching of human adenovirus 2: structure of the core. J Virol. 1984; 51(1):52-6. PMC: 254398. DOI: 10.1128/JVI.51.1.52-56.1984. View

17.

Shayakhmetov D, Li Z, Gaggar A, Gharwan H, Ternovoi V, Sandig V . Genome size and structure determine efficiency of postinternalization steps and gene transfer of capsid-modified adenovirus vectors in a cell-type-specific manner. J Virol. 2004; 78(18):10009-22. PMC: 514985. DOI: 10.1128/JVI.78.18.10009-10022.2004. View

18.

Fabry C, Rosa-Calatrava M, Conway J, Zubieta C, Cusack S, Ruigrok R . A quasi-atomic model of human adenovirus type 5 capsid. EMBO J. 2005; 24(9):1645-54. PMC: 1142584. DOI: 10.1038/sj.emboj.7600653. View

19.

Bett A, Prevec L, Graham F . Packaging capacity and stability of human adenovirus type 5 vectors. J Virol. 1993; 67(10):5911-21. PMC: 238011. DOI: 10.1128/JVI.67.10.5911-5921.1993. View

20.

Chatterjee P, Vayda M, Flint S . Interactions among the three adenovirus core proteins. J Virol. 1985; 55(2):379-86. PMC: 254944. DOI: 10.1128/JVI.55.2.379-386.1985. View