MPEx: a Tool for Exploring Membrane Proteins

Overview

Journal Protein Sci

Specialty Biochemistry

Date 2009 Sep 29

PMID 19785006

Citations 150

Authors

Craig Snider

Sajith Jayasinghe

Kalina Hristova

Stephen H White

Affiliations

Soon will be listed here.

Abstract

Hydropathy plot methods form a cornerstone of membrane protein research, especially in the early stages of biochemical and structural characterization. Membrane Protein Explorer (MPEx), described in this article, is a refined and versatile hydropathy-plot software tool for analyzing membrane protein sequences. MPEx is highly interactive and facilitates the characterization and identification of favorable protein transmembrane regions using experiment-based physical and biological hydrophobicity scales. Besides allowing the consequences of sequence mutations to be examined, it provides tools for aiding the design of membrane-active peptides. MPEx is freely available as a Java Web Start application from our web site at http://blanco.biomol.uci.edu/mpex.

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