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PepAnalyzer: Predicting Peptide Properties Using Its Sequence

Overview
Journal Amino Acids
Specialty Biochemistry
Date 2023 Sep 5
PMID 37668712
Authors
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Abstract

Peptides are short linear molecules consisting of amino acids that play an essential role in most biological processes. They can treat diseases by working as a vaccine or antimicrobial agent and serves as a cancer molecule to deliver the drug to the target site for the treatment of cancer. They have the potential to solve the drawbacks of current medications and can be industrially produced in large quantities at low cost. However, poor chemical and physical stability, short circulating plasma half-life, and solubility are some issues that need solutions before they can be used as therapeutics. PepAnalyzer tool is a user-friendly tool that predicts 15 different properties such as binding potential, half-life, transmembrane patterns, test tube stability, charge, isoelectric point, molecular weights, and molar extinction coefficients only using the sequence. The tool is designed using BioPython utility and has even results with standard tools, such as Expasy, EBI, Genecorner, and Geneinfinity. The tool assists students, researchers, and the pharmaceutical sector. The PepAnalyzer tool's online platform is accessible at the link: http://www.iksmbrlabdu.in/peptool .

Citing Articles

Peptide-based drug discovery through artificial intelligence: towards an autonomous design of therapeutic peptides.

Goles M, Daza A, Cabas-Mora G, Sarmiento-Varon L, Sepulveda-Yanez J, Anvari-Kazemabad H Brief Bioinform. 2024; 25(4).

PMID: 38856172 PMC: 11163380. DOI: 10.1093/bib/bbae275.

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