Omega-1, a Glycoprotein Secreted by Schistosoma Mansoni Eggs, Drives Th2 Responses

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2009 Jul 29

PMID 19635864

Citations 201

Authors

Bart Everts

Georgia Perona-Wright

Hermelijn H Smits

Cornelis H Hokke

Alwin J van der Ham

Colin M Fitzsimmons

Michael J Doenhoff

Jurgen van der Bosch

Katja Mohrs

Helmut Haas

Markus Mohrs

Maria Yazdanbakhsh

Gabriele Schramm

Affiliations

Soon will be listed here.

Abstract

Soluble egg antigens of the parasitic helminth Schistosoma mansoni (S. mansoni egg antigen [SEA]) induce strong Th2 responses both in vitro and in vivo. However, the specific molecules that prime the development of Th2 responses have not been identified. We report that omega-1, a glycoprotein which is secreted from S. mansoni eggs and present in SEA, is capable of conditioning human monocyte-derived dendritic cells in vitro to drive T helper 2 (Th2) polarization with similar characteristics as whole SEA. Furthermore, using IL-4 dual reporter mice, we show that both natural and recombinant omega-1 alone are sufficient to generate Th2 responses in vivo, even in the absence of IL-4R signaling. Finally, omega-1-depleted SEA displays an impaired capacity for Th2 priming in vitro, but not in vivo, suggesting the existence of additional factors within SEA that can compensate for the omega-1-mediated effects. Collectively, we identify omega-1, a single component of SEA, as a potent inducer of Th2 responses.

Citing Articles

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