Natural Drugs Targeting Inflammation Pathways Can Be Used to Treat Atherosclerosis

Overview

Journal Front Pharmacol

Date 2022 Nov 17

PMID 36386165

Authors

Xiayinan Song

Xiaoming Wang

Danyang Wang

Zhenzhen Zheng

Jie Li

Yunlun Li

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis (AS) is the chronic gradual degradation of arteries in combination with inflammation. Currently, the main research focus has been on interactions between inflammatory cells, inflammatory mediators, and immune mechanisms, while some studies have reported natural drugs were exerting a critical role against AS, whereas the usage of natural drugs was always limited by various factors such as poor penetration across biological barriers, low bioavailability, and unclear mechanisms. Herein, we reviewed the potential targets for inflammation against AS, discussed the underlying mechanisms of natural drugs for AS, particularly highlighted the dilemma of current research, and finally, offered perspectives in this field.

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