Biosynthesis of Salinosporamides from Alpha,beta-unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2009 Jul 16

PMID 19601645

Citations 30

Authors

Yuan Liu

Christopher Hazzard

Alessandra S Eustaquio

Kevin A Reynolds

Bradley S Moore

Affiliations

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Abstract

A new series of coenzyme A-tethered polyketide synthase extender units were discovered in relation to the biosynthesis of the salinosporamide family of anticancer agents from the marine bacterium Salinispora tropica. In vivo and in vitro experiments revealed that the crotonyl-CoA reductase/carboxylase SalG has broad substrate tolerance toward 2-alkenyl-CoAs that give rise to the salinosporamide C-2 substitution pattern.

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