Phosphatidylinositol 3-kinase/Akt Pathway Targets Acetylation of Smad3 Through Smad3/CREB-binding Protein Interaction: Contribution to Transforming Growth Factor Beta1-induced Epstein-Barr Virus Reactivation

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2009 Jul 11

PMID 19589780

Citations 14

Authors

Lassad Oussaief

Aurelie Hippocrate

Vanessa Ramirez

Aurore Rampanou

Wei Zhang

David Meyers

Philip Cole

Ridha Khelifa

Irene Joab

Affiliations

Soon will be listed here.

Abstract

Epstein-Barr virus, a ubiquitous human herpesvirus, is associated with the development of carcinomas and lymphomas. We previously showed that transforming growth factor beta1 (TGF-beta1) mediated the virus to enter the lytic cycle, which is triggered by expression of Z Epstein-Barr virus replication activator (ZEBRA), through the ERK 1/2 MAPK signaling pathway. We report here that Akt, activated downstream from ERK 1/2, was required for TGF-beta1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-beta1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein and then to regulate TGF-beta1-induced ZEBRA expression.

Citing Articles

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