» Articles » PMID: 19568797

What Do Diffusion Measurements Tell Us About Membrane Compartmentalisation? Emergence of the Role of Interprotein Interactions

Overview
Journal J Chem Biol
Specialty Biochemistry
Date 2009 Jul 2
PMID 19568797
Citations 13
Authors
Affiliations
Soon will be listed here.
Abstract

The techniques of diffusion analysis based on optical microscopy approaches have revealed a great diversity of the dynamic organisation of cell membranes. For a long period, two frameworks have dominated the way of representing the membrane structure: the membrane skeleton fences and the lipid raft models. Progresses in the methods of data analysis have shed light on the features and consequently the possible origin of membrane domains: Inter-protein interactions play a role in confinement. Innovative developments pushing forward the spatiotemporal resolution limits are currently emerging, which are likely to provide in the future a detailed understanding of the intimate functional dynamic organisation of the cell membrane.

Citing Articles

Intratumoral nanofluidic system enhanced tumor biodistribution of PD-L1 antibody in triple-negative breast cancer.

Liu H, Capuani S, Badachhape A, Di Trani N, Davila Gonzalez D, Vander Pol R Bioeng Transl Med. 2023; 8(6):e10594.

PMID: 38023719 PMC: 10658527. DOI: 10.1002/btm2.10594.


Exploring the influence of cytosolic and membrane FAK activation on YAP/TAZ nuclear translocation.

Eroume K, Cavill R, Stankova K, de Boer J, Carlier A Biophys J. 2021; 120(20):4360-4377.

PMID: 34509508 PMC: 8553670. DOI: 10.1016/j.bpj.2021.09.009.


High-Precision Protein-Tracking With Interferometric Scattering Microscopy.

Taylor R, Holler C, Mahmoodabadi R, Kuppers M, Dastjerdi H, Zaburdaev V Front Cell Dev Biol. 2020; 8:590158.

PMID: 33224953 PMC: 7669747. DOI: 10.3389/fcell.2020.590158.


Motifs and interface amino acid-mediated regulation of amyloid biogenesis in microbes to humans: potential targets for intervention.

Beg A, Khan A Biophys Rev. 2020; 12(5):1249-1256.

PMID: 32930961 PMC: 7575677. DOI: 10.1007/s12551-020-00759-5.


Dynamic heterogeneity and non-Gaussian statistics for ganglioside GM1s and acetylcholine receptors on live cell membrane.

He W, Su Y, Peng H, Tong P Mol Biol Cell. 2020; 31(13):1380-1391.

PMID: 32348189 PMC: 7353135. DOI: 10.1091/mbc.E19-08-0473.


References
1.
Fujiwara T, Ritchie K, Murakoshi H, Jacobson K, Kusumi A . Phospholipids undergo hop diffusion in compartmentalized cell membrane. J Cell Biol. 2002; 157(6):1071-81. PMC: 2174039. DOI: 10.1083/jcb.200202050. View

2.
Munro S . Lipid rafts: elusive or illusive?. Cell. 2003; 115(4):377-88. DOI: 10.1016/s0092-8674(03)00882-1. View

3.
Jacquier V, Prummer M, Segura J, Pick H, Vogel H . Visualizing odorant receptor trafficking in living cells down to the single-molecule level. Proc Natl Acad Sci U S A. 2006; 103(39):14325-30. PMC: 1599963. DOI: 10.1073/pnas.0603942103. View

4.
Bouzigues C, Morel M, Triller A, Dahan M . Asymmetric redistribution of GABA receptors during GABA gradient sensing by nerve growth cones analyzed by single quantum dot imaging. Proc Natl Acad Sci U S A. 2007; 104(27):11251-6. PMC: 2040885. DOI: 10.1073/pnas.0702536104. View

5.
Sabra M, Mouritsen O . Steady-state compartmentalization of lipid membranes by active proteins. Biophys J. 1998; 74(2 Pt 1):745-52. PMC: 1302555. DOI: 10.1016/S0006-3495(98)73999-2. View